ArticlePLoS neglected tropical diseases2018
Multi-drug resistant non-typhoidal Salmonella associated with invasive disease in western Kenya.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017.The Lancet. Infectious diseases · 2019Pooled it
- Incidence and antimicrobial resistance of non-typhoidal Salmonella enterica in stool samples from children under five in peri-urban Ouagadougou, Burkina Faso.BMC microbiology · 2025Article
- Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi.Nature communications · 2025Article
- Phenotypic and potential virulence features of Salmonella enterica serotypes from cancer patients in Kolkata, India.BMC infectious diseases · 2025Article
- Prevalence, antimicrobial resistance pattern, and associated factors of Salmonella serovars among human-animal interfaces in the Amhara National Regional State, Ethiopia.BMC infectious diseases · 2025Article
- Molecular epidemiology ofAntimicrobial agents and chemotherapy · 2025Article
- Effectiveness of iNTS vaccination in sub-Saharan Africa.Scientific reports · 2025Article
- Severe outcomes and risk factors of non-neutropenic fever episodes in hospitalized children with cancer in Kenya.Frontiers in oncology · 2025Article
- Shedding of nontyphoidalJournal of clinical microbiology · 2024Article
- Characterization ofFrontiers in microbiology · 2024Article
- Ceftriaxone-resistantFrontiers in public health · 2024Article
- Non-typhoidal salmonella contamination along the pork value chain in a rural East African setting: a cross-sectional study.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2023Article
- Article
- What is the Source of Infections Causing Invasive NontyphoidalOpen forum infectious diseases · 2023Review
- Invasive non-typhoidalFrontiers in microbiology · 2023Article
- Case-control investigation of invasive Salmonella disease in Malawi reveals no evidence of environmental or animal transmission of invasive strains, and supports human to human transmission.PLoS neglected tropical diseases · 2022Article
- Article
- First study on virulence genes, antimicrobial resistance, and integrons inVeterinary world · 2022Article
- Genomic characterization of invasive typhoidal and non-typhoidal Salmonella in southwestern Nigeria.PLoS neglected tropical diseases · 2022Article
- Factors Associated with Multi-Drug-Resistant Non-TyphoidalInfection and drug resistance · 2022Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Non-typhoidal Salmonella (NTS) is a leading cause of bloodstream infections in Africa, but the various contributions of host susceptibility versus unique pathogen virulence factors are unclear. We used data from a population-based surveillance platform (population ~25,000) between 2007-2014 and NTS genome-sequencing to compare host and pathogen-specific factors between individuals presenting with NTS bacteremia and those presenting with NTS diarrhea. Salmonella Typhimurium ST313 and Salmonella Enteritidis ST11 were the most common isolates. Multi-drug resistant strains of NTS were more commonly isolated from patients presenting with NTS bacteremia compared to NTS diarrhea. This relationship was observed in patients under age five [aOR = 15.16, 95% CI (2.84-81.05), P = 0.001], in patients five years and older, [aOR = 6.70 95% CI (2.25-19.89), P = 0.001], in HIV-uninfected patients, [aOR = 21.61, 95% CI (2.53-185.0), P = 0.005], and in patients infected with Salmonella serogroup B [aOR = 5.96, 95% CI (2.28-15.56), P < 0.001] and serogroup D [aOR = 14.15, 95% CI (1.10-182.7), P = 0.042]. Thus, multi-drug-resistant NTS was strongly associated with bacteremia compared to diarrhea among children and adults. This association was seen in HIV-uninfected individuals infected with either S. Typhimurium or S. Enteritidis. Risk of developing bacteremia from NTS infection may be driven by virulence properties of the Salmonella pathogen.
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