ArticlePLoS neglected tropical diseases2018
Isolation and complete genome analysis of neurotropic dengue virus serotype 3 from the cerebrospinal fluid of an encephalitis patient.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia.PloS one · 2018Trial
- NS2A V89F mutation in a DENV1 clinical isolate enhances neurotropism and neuroinvasion.Frontiers in cellular and infection microbiology · 2026Article
- Detection of dengue virus encephalitis in central part of Sri Lanka.World journal of virology · 2025Article
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- Diagnostic challenges of arboviral infections and dengue virus serotype distribution in febrile patients in East Java, Indonesia.IJID regions · 2025Article
- Dengue encephalopathy in an adult due to dengue virus type 1 infection.BMC infectious diseases · 2024Article
- Effective Infection with Dengue Virus in Experimental Neonate and Adult Mice through the Intranasal Route.Viruses · 2022Article
- Detection of dengue virus serotype 1 in central nervous system of a child in Bandung, West Java: A case report.SAGE open medical case reports · 2021Article
- Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.PLoS neglected tropical diseases · 2020Article
- Pathogenic viruses: Molecular detection and characterization.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Review
- Article
- Dengue infection in mice inoculated by the intracerebral route: neuropathological effects and identification of target cells for virus replication.Scientific reports · 2019Article
- Dengue hemorrhagic fever presenting as encephalitis: a case report.Journal of medical case reports · 2019Article
- High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis, and meningitis. A narrative review and clinical appraisal.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2019Review
- Article
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16 authors.
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Abstract
Although neurological manifestations associated with dengue viruses (DENV) infection have been reported, there is very limited information on the genetic characteristics of neurotropic DENV. Here we describe the isolation and complete genome analysis of DENV serotype 3 (DENV-3) from cerebrospinal fluid of an encephalitis paediatric patient in Jakarta, Indonesia. Next-generation sequencing was employed to deduce the complete genome of the neurotropic DENV-3 isolate. Based on complete genome analysis, two unique and nine uncommon amino acid changes in the protein coding region were observed in the virus. A phylogenetic tree and molecular clock analysis revealed that the neurotropic virus was a member of Sumatran-Javan clade of DENV-3 genotype I and shared a common ancestor with other isolates from Jakarta around 1998. This is the first report of neurotropic DENV-3 complete genome analysis, providing detailed information on the genetic characteristics of this virus.
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