Evidence map›Paper›PMID 29329274›Full record

ReviewSensors (Basel, Switzerland)2018

Current Technologies of Electrochemical Immunosensors: Perspective on Signal Amplification.

Il-Hoon Cho, Jongsung Lee, Jiyeon Kim, Min-Soo Kang, Jean Kyung Paik, Seockmo Ku, Hyun-Mo Cho, Joseph Irudayaraj, Dong-Hyung Kim

Open access · goldAbstract readReview
In one paragraph

Review in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 218 citations in OpenAlex.

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  16. microRNA Detection via Nanostructured Biochips for Early Cancer Diagnostics.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Il-Hoon ChoDepartment of Biomedical Laboratory Science, College of Health Science, Eulji University, Seongnam 13135, Korea. ihcho@eulji.ac.kr.
Jongsung LeeDepartment of Genetic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon City, Gyunggi Do 164-19, Korea. bioneer@skku.edu.ORCID 0000-0002-5073-2619
Jiyeon KimDepartment of Biomedical Laboratory Science, School of Medicine, Eulji University, Daejeon 34824, Korea. yeon@eulji.ac.kr.
Min-Soo KangDepartment of Medical IT Marketing, College of Health Industry, Eulji University, Seongnam 13135, Korea. mskang@eulji.ac.kr.
Jean Kyung PaikDepartment of Food and Nutrition, Eulji University, Seongnam 13135, Korea. jkpaik@eulji.ac.kr.
Seockmo KuFermentation Science Program, School of Agribusiness and Agriscience, College of Basic and Applied Sciences, Middle Tennessee State University, Murfreesboro, TN 37132, USA. seockmo.ku@mtsu.edu.
Hyun-Mo ChoKorea Research Institute of Standards and Science, P.O. Box 102, Yuseong, Daejon 34113, Korea. hmcho@kriss.re.kr.
Joseph IrudayarajDepartment of Agricultural and Biological Engineering, Bindley Bioscience Center, Purdue Center for Cancer Research, Purdue University, 225 South University Street, West Lafayette, IN 47907, USA. josephi@purdue.edu.
Dong-Hyung KimKorea Research Institute of Standards and Science, P.O. Box 102, Yuseong, Daejon 34113, Korea. donghyung.kim@kriss.re.kr.
Eulji University · KRKorea Research Institute of Standards and Science · KRMiddle Tennessee State University · USPurdue University West Lafayette · USSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An electrochemical immunosensor employs antibodies as capture and detection means to produce electrical charges for the quantitative analysis of target molecules. This sensor type can be utilized as a miniaturized device for the detection of point-of-care testing (POCT). Achieving high-performance analysis regarding sensitivity has been one of the key issues with developing this type of biosensor system. Many modern nanotechnology efforts allowed for the development of innovative electrochemical biosensors with high sensitivity by employing various nanomaterials that facilitate the electron transfer and carrying capacity of signal tracers in combination with surface modification and bioconjugation techniques. In this review, we introduce novel nanomaterials (e.g., carbon nanotube, graphene, indium tin oxide, nanowire and metallic nanoparticles) in order to construct a high-performance electrode. Also, we describe how to increase the number of signal tracers by employing nanomaterials as carriers and making the polymeric enzyme complex associated with redox cycling for signal amplification. The pros and cons of each method are considered throughout this review. We expect that these reviewed strategies for signal enhancement will be applied to the next versions of lateral-flow paper chromatography and microfluidic immunosensor, which are considered the most practical POCT biosensor platforms.

Indexed as

Electrochemical TechniquesBiosensing TechniquesGoldImmunoassayMetal NanoparticlesGoldelectrochemical immunosensorelectrode scaffoldlabeling techniquesnanomaterialspoint-of-care testingsignal amplification

Identifiers

PMID29329274
PMCPMC5796447
OpenAlexW2783754090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.