ArticleNutrients2018
Population Reference Values for Serum Methylmalonic Acid Concentrations and Its Relationship with Age, Sex, Race-Ethnicity, Supplement Use, Kidney Function and Serum Vitamin B12 in the Post-Folic Acid Fortification Period.
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Association Between Methylmalonic Acid and Cognition: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Metabolomic signatures of extreme old age: findings from the New England Centenarian Study.GeroScience · 2026Article
- METABOLOMIC SIGNATURES OF EXTREME OLD AGE: FINDINGS FROM THE NEW ENGLAND CENTENARIAN STUDY.bioRxiv : the preprint server for biology · 2025Article
- The mechanism of enterogenous toxin methylmalonic acid aggravating calcium-phosphorus metabolic disorder in uremic rats by regulating the Wnt/β-catenin pathway.Molecular medicine (Cambridge, Mass.) · 2025Article
- Association analysis between circulating methylmalonic acid and cognitive performance: a population-based cross-sectional study.Frontiers in neurology · 2025Article
- Article
- Mitochondrial dysfunction-related metabolite methylmalonic acid is associated with decreased cognitive performance.PloS one · 2025Article
- Aging-accumulated methylmalonic acid serum levels at breast cancer diagnosis are not associated with distant metastases.Breast cancer research and treatment · 2024Article
- Serum methylmalonic acid concentrations at breast cancer diagnosis significantly correlate with clinical frailty.GeroScience · 2024Article
- Impact of metformin treatment on cobalamin status in persons with type 2 diabetes.Nutrition reviews · 2024Review
- Methylmalonic acid in aging and disease.Trends in endocrinology and metabolism: TEM · 2024Review
- Inverted U-shaped relationship between serum vitamin B12 and α-Klotho levels in US adults: a cross-sectional study.Frontiers in nutrition · 2024Article
- Folate and vitamin B12 usual intake and biomarker status by intake source in United States adults aged ≥19 y: NHANES 2007-2018.The American journal of clinical nutrition · 2023Article
- Sexual dimorphism in mitochondrial dysfunction and diabetes mellitus: evidence from a population-based cohort study.Diabetology & metabolic syndrome · 2023Article
- Nonlinear associations of serum cobalamin with risk of all-cause and cardiovascular mortality in hypertensive adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Biomarkers for drug development in propionic and methylmalonic acidemias.Journal of inherited metabolic disease · 2022Review
- Macro-BBMJ case reports · 2022Article
- Associations of Circulating Methylmalonic Acid and Vitamin B-12 Biomarkers Are Modified by Vegan Dietary Pattern in Adult and Elderly Participants of the Adventist Health Study 2 Calibration Study.Current developments in nutrition · 2020Article
- Folate status in the US population 20 y after the introduction of folic acid fortification.The American journal of clinical nutrition · 2019Article
- Age-specific reference ranges are needed to interpret serum methylmalonic acid concentrations in the US population.The American journal of clinical nutrition · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum methylmalonic acid (MMA) is elevated in vitamin B-12 deficiency and in kidney dysfunction. Population reference values for serum MMA concentrations in post-folic acid fortification period are lacking. Aims of this study were to report the population reference values for serum MMA and to evaluate the relation between serum MMA and sex, age, race-ethnicity, kidney dysfunction and vitamin B-12. We used data from three National Health and Nutrition Examination Surveys, 1999-2000, 2001-2002 and 2003-2004 conducted after folic acid fortification commenced (
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Registered trials
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