ArticleCell2018
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05504850 (The Feasibility and Acceptability of a Multicultural Healthy Diet), which is not on this map. Cited by 661 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
661citing papers in PubMed, 1 pooled it
44.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Feasibility and Acceptability of a Multicultural Healthy Diet (Anti-inflammatory Dietary Pattern) in Racial/Ethnic Minorities With Chronic Kidney Disease
Who cites it
661 citing papers in PubMed, 1 synthesis or guideline pooled it, 995 citations in OpenAlex.
- Trained immunity in inflammatory bone disease: a bibliometric and literature-level text-mining analysis.Frontiers in immunology · 2026Pooled it
- Effect of 2 Weeks of Time-Restricted Eating on Innate Immunity and Systemic Inflammation in Patients With a History of Myocardial Infarction: A Randomized-Controlled Crossover Study.Journal of the American Heart Association · 2026Trial
- Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial.American journal of respiratory and critical care medicine · 2025Trial
- Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial.Nature medicine · 2025Trial
- Gut microbiota and immunometabolism in obesity.Gut microbes · 2026Review
- The epigenetic-metabolic axis of trained immunity: dual roles in disease pathogenesis and intervention.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Trained immunity in chronic, relapsing and low-grade joint inflammation.Nature reviews. Rheumatology · 2026Review
- The H3K27me3-NR1D1-IFN-γ axis in trained macrophages induced by early respiratory virus infection drives non-T2 asthma in children.Cellular & molecular immunology · 2026Article
- Trained Immunity as a Mechanistic Bridge Between Uremic Toxins, Atherosclerosis, and Vascular Calcification in Chronic Kidney Disease.Cardiovascular toxicology · 2026Review
- Nucleotide metabolic reprogramming: a "double-edged sword" in obesity-related inflammation-from metabolic adaptation to pathological imbalance.Journal of physiology and biochemistry · 2026Review
- Drugging trained immunity: immunometabolic and epigenetic control of maladaptive inflammatory memory in chronic inflammatory diseases.Immunologic research · 2026Review
- Review
- Maladaptive trained immunity as a hematopoietic stem cell driver of inflammaging.Nature aging · 2026Article
- Trained immunity links hematopoietic stem cell aging to aging-associated inflammation.Nature aging · 2026Article
- Trained immunity: New insights into pathogenesis and therapeutic targets in diabetes and diabetic complications.Genes & diseases · 2026Review
- Polymicrobial-driven NLRP6 inflammasome regulates IL-1β production and alveolar bone loss in a murine model of periodontitis.PLoS pathogens · 2026Article
- Isocaloric switch from low-fat to Western high-fat diet triggers transcriptomic reprogramming and ectopic olfactory receptor responses.Science advances · 2026Article
- Mesenchymal stromal cells immunosuppress osteoarthritis synovial fluid modulated monocytes via IL-6 and CCL2.Cell death & disease · 2026Article
- Trained Immunity in Host Defense: Mechanisms, Pathogen Interactions, and Therapeutic Potential.Pathogens (Basel, Switzerland) · 2026Review
- Review
601 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 13 institutions in 4 countries.
Anette ChristInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases & Immunology, UMass Medical School, Worcester, MA 01605, USA.
Patrick GüntherDepartment for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
Mario A R LauterbachInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.
Peter DuewellCenter of Integrated Protein Science Munich (CIPSM) and Division of Clinical Pharmacology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, 80337 Munich, Germany.
Debjani BiswasDepartment of Infectious Diseases & Immunology, UMass Medical School, Worcester, MA 01605, USA.
Karin PelkaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Claus J ScholzDepartment for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
Marije OostingDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Kristian HaendlerDepartment for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
Kevin BaßlerDepartment for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
Kathrin KleeDepartment for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
Jonas Schulte-SchreppingDepartment for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
Thomas UlasDepartment for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
Simone J C F M MoorlagDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Vinod KumarDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Min Hi ParkLipid Metabolism Unit, Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, 77845 College Station, TX, USA.
Leo A B JoostenDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Laszlo A GrohDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Niels P RiksenDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Terje EspevikCentre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Andreas SchlitzerDepartment for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
Yang LiDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Michael L FitzgeraldLipid Metabolism Unit, Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Mihai G NeteaDepartment for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Joachim L SchultzeDepartment for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
Eicke LatzInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases & Immunology, UMass Medical School, Worcester, MA 01605, USA; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Electronic address: eicke.latz@uni-bonn.de.
University of Bonn · DERadboud University Nijmegen · NLUniversity of Massachusetts Chan Medical School · USRadboud University Medical Center · NLBroad Institute · USCenter for Integrated Protein Science Munich · DEGerman Center for Neurodegenerative Diseases · DEHarvard University · USMassachusetts General Hospital · USNorwegian University of Science and Technology · NOUniversity Medical Center · USUniversity Medical Center Groningen · NLUniversity of Groningen · NL
Funding
HIV Disease and Impairement of High Density Lipoprotein MetabolismR01HL101274 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI BUKRINSKY, MICHAEL ILYA, FITZGERALD, MICHAEL LEO · 2010 to 2015
$4.0MHDL prevention of cholesterol crystal inflammation in HIV diseaseR01HL112661 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FITZGERALD, MICHAEL LEO, LATZ, EICKE · 2012 to 2016
$3.1MEpigenetic Reprogramming in AtherosclerosisR01HL131624 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, MICHAEL LEO, LATZ, EICKE · 2017 to 2020
$2.7MEuropean Research Council 310372NHLBI NIH HHS R01 HL101274NHLBI NIH HHS R01 HL112661NHLBI NIH HHS R01 HL131624
Abstract
Long-term epigenetic reprogramming of innate immune cells in response to microbes, also termed "trained immunity," causes prolonged altered cellular functionality to protect from secondary infections. Here, we investigated whether sterile triggers of inflammation induce trained immunity and thereby influence innate immune responses. Western diet (WD) feeding of Ldlr
Indexed as
Cellular ReprogrammingDiet, WesternEpigenesis, GeneticImmunity, InnateImmunologic MemoryAdultAgedAnimalsCells, CulturedFemaleHumansLipoproteins, LDLMaleMiceMice, Inbred C57BLMiddle AgedLipoproteins, LDLNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReceptors, LDLASCatherosclerosisepigenetic reprogramminggranulocyte macrophage progenitorsinnate immune memoryNLRP3 inflammasomenon-communicable diseasessterile inflammationtrained immunityWestern diet feeding
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT05504850ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.