SynthesisOncology reports2018
Meta-analysis of mRNA expression profiles to identify differentially expressed genes in lung adenocarcinoma tissue from smokers and non-smokers.
Synthesis in Oncology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis.Cellular and molecular life sciences : CMLS · 2024Review
- Article
- Article
- Article
- Differential expression of lung adenocarcinoma transcriptome with signature of tobacco exposure.Journal of applied genetics · 2020Article
- A pilot study of cdc6 as a biomarker for circulating tumor cells in patients with lung cancer.Journal of clinical laboratory analysis · 2020Article
- Identification of potential key genes and pathways in hepatitis B virus-associated hepatocellular carcinoma by bioinformatics analyses.Oncology letters · 2020Article
- Analysis of four complete linkage sequence variants within a novel lncRNA located in a growth QTL on chromosome 1 related to growth traits in chickens.Journal of animal science · 2020Article
- The comprehensive investigation of transcription factor AP-2 alpha in lung adenocarcinoma.Translational cancer research · 2020Article
- Identification of differentially expressed protein-coding genes in lung adenocarcinomas.Experimental and therapeutic medicine · 2020Article
- Article
- Construction and validation of a 6-gene nomogram discriminating lung metastasis risk of breast cancer patients.PloS one · 2020Article
- Identification of differentially expressed genes in small and non-small cell lung cancer based on meta-analysis of mRNA.Heliyon · 2019Article
- A 5-gene prognostic nomogram predicting survival probability of glioblastoma patients.Brain and behavior · 2019Article
- Clinical Significance And Integrative Analysis Of Kinesin Family Member 18B In Lung Adenocarcinoma.OncoTargets and therapy · 2019Article
- Downregulation of miR‑224‑5p in prostate cancer and its relevant molecular mechanism via TCGA, GEO database and in silico analyses.Oncology reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compared to other types of lung cancer, lung adenocarcinoma patients with a history of smoking have a poor prognosis during the treatment of lung cancer. How lung adenocarcinoma-related genes are differentially expressed between smoker and non-smoker patients has yet to be fully elucidated. We performed a meta-analysis of four publicly available microarray datasets related to lung adenocarcinoma tissue in patients with a history of smoking using R statistical software. The top 50 differentially expressed genes (DEGs) in smoking vs. non‑smoking patients are shown using heat maps. Additionally, we conducted KEGG and GO analyses. In addition, we performed a PPI network analysis for 8 genes that were selected during a previous analysis. We identified a total of 2,932 DEGs (1,806 upregulated, 1,126 downregulated) and five genes (CDC45, CDC20, ANAPC7, CDC6, ESPL1) that may link lung adenocarcinoma to smoking history. Our study may provide new insights into the complex mechanisms of lung adenocarcinoma in smoking patients, and our novel gene expression signatures will be useful for future clinical studies.
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