ArticleInternational journal of molecular medicine2018
Genistein attenuates di‑(2‑ethylhexyl) phthalate-induced testicular injuries via activation of Nrf2/HO‑1 following prepubertal exposure.
Article in International journal of molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Sulforaphane substantially impedes testicular ferroptosis in adult rats exposed to di-2-ethylhexyl phthalate through activation of NRF-2/SLC7A11/GPX-4 trajectory.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Investigation of protective effects of rutin\cyclodextrin inclusion complex against testicular damage caused by diisononyl phthalate in rats.Iranian journal of basic medical sciences · 2025Article
- Testicular protective effects of hesperidin against chemical and biological toxicants.Toxicology research · 2024Review
- The Role of Genistein in Mammalian Reproduction.Molecules (Basel, Switzerland) · 2023Review
- Immature rat testis sustained long-term development using an integrative model.Biological research · 2022Article
- Technologies for Solubility, Dissolution and Permeation Enhancement of Natural Compounds.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Quercetin ameliorates Di (2-ethylhexyl) phthalate-induced nephrotoxicity by inhibiting NF-κB signaling pathway.Toxicology research · 2022Article
- Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure.Environmental science and pollution research international · 2022Article
- Duration-dependent effects of high dose of phthalate exposure on semen quality in adult male rats.JBRA assisted reproduction · 2022Article
- 10Frontiers in cell and developmental biology · 2022Article
- Mechanistic insight into toxicity of phthalates, the involved receptors, and the role of Nrf2, NF-κB, and PI3K/AKT signaling pathways.Environmental science and pollution research international · 2021Review
- Reproductive injury in male BALB/c mice infected with Neospora caninum.Parasites & vectors · 2021Article
- The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging.Oxidative medicine and cellular longevity · 2021Review
- Oxidative Stress Disrupted Prepubertal Rat Testicular Development after Xenotransplantation.Oxidative medicine and cellular longevity · 2021Article
- The gut-microbiota-testis axis mediated by the activation of the Nrf2 antioxidant pathway is related to prepuberal steroidogenesis disorders induced by di-(2-ethylhexyl) phthalate.Environmental science and pollution research international · 2020Article
- Low Dose of Genistein Alleviates Mono-(2-Ethylhexyl) Phthalate-Induced Fetal Testis Disorder Based on Organ Culture Model.Oxidative medicine and cellular longevity · 2020Article
- Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle.Theranostics · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Di‑(2‑ethylhexyl) phthalate (DEHP) and genistein (GEN) are of the most common endocrine disrupting chemicals (EDCs) present in the environment or the diet. However, investigation of the effects of acute exposure to these two EDCs during prepuberty has been lacking. In this study, DEHP and GEN were administrated to prepubertal male Sprague‑Dawley rats by gavage from PND22 to PND35 with vehicle control, GEN 50 mg/kg body weight (bw)/day, DEHP50, 150 and 450 mg/kg bw/day, and combined treatment. Reproductive parameters including testis weight, anogenital distance and organ coefficient were evaluated on PND36. Enzyme activity involved in the regulation of testicular redox state as well as expression of genes and proteins related to anti-oxidative ability and apoptosis were also investigated. The results revealed that by PND36, DEHP treatment had significantly decreased the testis weight, organ coefficient, testicular anti-oxidative enzyme activities and caused tubular vacuolation; however, co‑administration of GEN partially alleviated DEHP‑induced testicular injuries and enhanced testicular anti‑oxidative enzyme activities and upregulated the expression of NF‑E2 related factor 2 and heme oxygenase‑1, which indicated that GEN partially attenuated DEHP‑induced male reproductive system damage through anti‑oxidative action following acute prepubertal exposure to DEHP. Thus, GEN may have use in attenuating the damaging effects of other EDCs that lead to reproductive disorders.
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