Evidence map›Paper›PMID 29328237›Full record

ArticleOptics letters2018

Visible light optical coherence microscopy of the brain with isotropic femtoliter resolution in vivo.

Conrad William Merkle, Shau Poh Chong, Aaron Michael Kho, Jun Zhu, Alfredo Dubra, Vivek Jay Srinivasan

Abstract read
In one paragraph

Article in Optics letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Conrad William Merkle
Shau Poh Chong
Aaron Michael Kho
Jun Zhu
Alfredo Dubra
Vivek Jay Srinivasan
University of California, Davis · USSmith-Kettlewell Eye Research Institute · US

Funding

Platform Technologies for Microscopic Retinal Imaging: Development & TranslationU01EY025477 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2015 to 2019
$4.4M
Axially-resolved Spectroscopic Ophthalmic ImagingR01EY025231 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2015 to 2019
$1.9M
Imaging Neuronal and Capillary Dysfunction Deep in the Rodent Brain in vivo Using 1700 NM Optical Coherence Microscopy and Tracer-Based KineticsR01NS094681 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2015 to 2019
$1.6M
Development, Validation and Application of Metabolic Imaging in GlaucomaR01EY028287 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO, GOLDBERG, JEFFREY L · 2017 to 2019
$1.1M
Interferometric Near-Infrared Spectroscopy for Tissue Flowmetry and OximetryR21NS105043 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2017 to 2018
$432k
Improving penetration depth and spatial resolution for in vivo deep imaging of mouse brain using 2200 nm Optical Coherence MicroscopyR03EB023591 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2017 to 2018
$157k
NEI NIH HHS R01 EY025231NEI NIH HHS R01 EY028287NEI NIH HHS U01 EY025477NIBIB NIH HHS R03 EB023591NINDS NIH HHS R01 NS094681NINDS NIH HHS R21 NS105043
6 · The paper itself

Abstract

Most flying-spot optical coherence tomography and optical coherence microscopy (OCM) systems use a symmetric confocal geometry, where the detection path retraces the illumination path starting from and ending with the spatial mode of a single-mode optical fiber. Here we describe a visible light OCM instrument that breaks this symmetry to improve transverse resolution without sacrificing collection efficiency in scattering tissue. This was achieved by overfilling a water immersion objective on the illumination path while maintaining a conventional Gaussian mode detection path (1/e

Indexed as

AnimalsBrainEquipment DesignImage EnhancementLightMiceMicroscopyOptical FibersTomography, Optical Coherence

Identifiers

PMID29328237
PMCPMC5953552
OpenAlexW2781658599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.