ArticlePhysiological measurement2018
In vivo neutron activation analysis of bone manganese in workers.
Article in Physiological measurement, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Measurement of sodium in soft tissue and bone in a sodium diet intervention study usingPhysiological measurement · 2025Article
- A methodology study for sodium quantification in bone and soft tissue based on in vivo neutron activation analysis using a two-compartment model.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2025Article
- Sensitivity improvement of a deuterium-deuterium neutron generator based in vivo neutron activation analysis (IVNAA) system.Physical and engineering sciences in medicine · 2025Article
- Dietary Intake of Multiple Nutrient Elements and Associated Health Effects in the Chinese General Population from a Total Diet Study.Nutrients · 2023Article
- Osteogenic Differentiation of Human Mesenchymal Stem Cells Modulated by Surface Manganese Chemistry in SLA Titanium Implants.BioMed research international · 2022Article
- Article
- Brain manganese and the balance between essential roles and neurotoxicity.The Journal of biological chemistry · 2020Review
- Characterization of bone aluminum, a potential biomarker of cumulative exposure, within an occupational population from Zunyi, China.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020Article
- The association of bone, fingernail and blood manganese with cognitive and olfactory function in Chinese workers.The Science of the total environment · 2019Article
- Development of a Cumulative Exposure Index (CEI) for Manganese and Comparison with Bone Manganese and Other Biomarkers of Manganese Exposure.International journal of environmental research and public health · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveManganese (Mn) is a neurotoxin. However, the impact of elevated, chronic Mn exposure is not well understood, partially due to the lack of a cumulative exposure biomarker. To address this gap, our group developed a compact in vivo neutron activation analysis (IVNAA) system to quantify Mn concentration in bone (MnBn). APPROACH: In this study, we used this system and determined MnBn among male Chinese workers and compared results to their blood Mn (MnB), a measure of recent exposure, and the years of employment, a measure of cumulative exposure. A cross-sectional study was conducted with 30 ferroalloy smelters (exposed) and 30 general manufacturing workers (controls). MnBn was assessed using IVNAA, MnB was measured with inductively coupled plasma mass spectrometry, and occupational history and demographics were obtained via questionnaire. Mn-doped phantoms were used to generate a calibration curve; spectra from these phantoms were consistent with in vivo spectra. MAIN
resultsThe median (interquartile range (IQR)) values for Mn biomarkers were 2.7 µg g SIGNIFICANCE: Our results support the use of IVNAA to quantify MnBn and the use of MnBn as a biomarker of cumulative Mn exposure.
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