Evidence map›Paper›PMID 29327782›Full record

ArticleNMR in biomedicine2018

Development of manganese-enhanced magnetic resonance imaging of the rostral ventrolateral medulla of conscious rats: Importance of normalization and comparison with other regions of interest.

Daniel J Huereca, Konstandinos A Bakoulas, Farhad Ghoddoussi, Bruce A Berkowitz, Avril Genene Holt, Patrick J Mueller

Open access · greenAbstract read
In one paragraph

Article in NMR in biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Subregional differences in GABAThe Journal of comparative neurology · 2020
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daniel J HuerecaDepartment of Pharmacology, Wayne State University School of Medicine, Detroit, MI, USA.
Konstandinos A BakoulasDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI, USA.
Farhad GhoddoussiDepartment of Anesthesiology, Wayne State University School of Medicine, Detroit, MI, USA.
Bruce A BerkowitzDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA.
Avril Genene HoltDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA.
Patrick J MuellerDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI, USA.ORCID 0000-0002-7720-1519
Wayne State University · US

Funding

Inactivity and Enhanced Sympathoexcitation: Role of Neuroplasticity in the RVLMR01HL096787 · NHLBI · WAYNE STATE UNIVERSITY · PI MUELLER, PATRICK J · 2010 to 2018
$3.2M
Novel Imaging of rod oxidative stress in retinal disease and treatment in vivoR01EY026584 · NEI · WAYNE STATE UNIVERSITY · PI BERKOWITZ, BRUCE A. · 2016 to 2019
$1.5M
Role of calcium channels in the development of diabetic retinopathyR21EY021619 · NEI · WAYNE STATE UNIVERSITY · PI BERKOWITZ, BRUCE A. · 2014 to 2015
$413k
Development of Effective Strategies for Tinnitus Diagnosis and TreatmentI01RX001095 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI HOLT, AVRIL GENENE · 2014 to 2017
–
NEI NIH HHS R01 EY026584NEI NIH HHS R21 EY021619NHLBI NIH HHS R01 HL096787RRD VA I01 RX001095
6 · The paper itself

Abstract

Spinally projecting neurons in the rostral ventrolateral medulla (RVLM) are believed to contribute to pathophysiological alterations in sympathetic nerve activity and the development of cardiovascular disease. The ability to identify changes in the activity of RVLM neurons in conscious animals and humans, especially longitudinally, would represent a clinically important advancement in our understanding of the contribution of the RVLM to cardiovascular disease. To this end, we describe the initial development of manganese-enhanced magnetic resonance imaging (MEMRI) for the rat RVLM. Manganese (Mn

Indexed as

ConsciousnessMagnetic Resonance ImagingAnimalsBody WeightCerebrospinal FluidImage Processing, Computer-AssistedMaleManganeseMedulla OblongataMicroinjectionsMusclesParaventricular Hypothalamic NucleusRats, Sprague-DawleySpinal CordTime FactorsManganesebrainstemconsciousimagingin vivoneuronal activity

Identifiers

PMID29327782
PMCPMC5819885
OpenAlexW2783729817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.