ArticleProteomics2018
The Saliva Proteome of Dogs: Variations Within and Between Breeds and Between Species.
Article in Proteomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Mass spectrometry-based proteomics profiling of dogs with and without oral diseases: a systematic review.BMC oral health · 2024Pooled it
- The Impacts of Ramadan Intermittent Fasting on Saliva Flow-Rate and Metabolic Data: A Systematic Review.Frontiers in nutrition · 2022Pooled it
- Canine Tear Proteomics: A New Frontier in Veterinary Ophthalmology.Veterinary ophthalmology · 2026Review
- Mass spectrometry-based serum peptidomic profiling reveals potential biomarker for canine hepatozoonosis.Scientific reports · 2025Article
- How the forensic multidisciplinary approach can solve a fatal dog pack attack.Forensic science, medicine, and pathology · 2024Article
- Species-level characterization of saliva and dental plaque microbiota reveals putative bacterial and functional biomarkers of periodontal diseases in dogs.FEMS microbiology ecology · 2024Article
- Dental erosion following clopidogrel administration in a dog: A case-based study.Veterinary medicine and science · 2024Article
- Correlation between Oxidative Stress Markers and Periodontal Disease in Dogs.Veterinary sciences · 2024Article
- Performance and overview of clinically relevant areas of application of saliva testing in the cat.Frontiers in veterinary science · 2024Review
- Characteristics of the Digestive Tract of Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- A Mass Spectrometric Approach to the Proteomic Profiling of theJournal of veterinary dentistry · 2022Article
- Article
- Survey of Saliva Components and Virus Sensors for Prevention of COVID-19 and Infectious Diseases.Biosensors · 2020Review
- Metabolome of canine and human saliva: a non-targeted metabolomics study.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Salivary proteomic profile of dogs with and without dental calculus.BMC veterinary research · 2020Article
- The parotid secretory protein BPIFA2 is a salivary surfactant that affects lipopolysaccharide action.Experimental physiology · 2020Article
- Urinary Proteome of Newborn Calves-New Potential in Non-Invasive Neonatal Diagnostic.Animals : an open access journal from MDPI · 2020Article
- Salivary proteomics of canine oral tumors using MALDI-TOF mass spectrometry and LC-tandem mass spectrometry.PloS one · 2019Article
- The Saliva Proteome of Dogs: Variations Within and Between Breeds and Between Species.Proteomics · 2018Article
- Comparative proteomic study of dog and human saliva.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saliva is a complex multifunctional fluid that bathes the oral cavity to assist in soft and hard tissue maintenance, lubrication, buffering, defense against microbes, and initiating digestion of foods. It has been extensively characterized in humans but its protein composition in dogs remains poorly characterized, yet saliva composition could explain (patho) physiological differences between individuals, breeds and with humans. This pilot discovery study aimed to characterize canine saliva from two breeds, Labrador retrievers and Beagles, and to compare this with human saliva using quantitative mass spectrometry. The analysis demonstrated considerable inter-individual variation and difference between breeds; however these were small in comparison to the differences between species. Functional mapping suggested roles of detected proteins similar to those found in human saliva with the exception of the initiation of digestion as salivary amylase was lacking or at very low abundance in canine saliva samples. Many potential anti-microbial proteins were detected agreeing with the notion that the oral cavity is under continuous microbial challenge.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.