Evidence map›Paper›PMID 29327206›Full record

ReviewMolecular neurobiology2018

Brain Photobiomodulation Therapy: a Narrative Review.

Farzad Salehpour, Javad Mahmoudi, Farzin Kamari, Saeed Sadigh-Eteghad, Seyed Hossein Rasta, Michael R Hamblin

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 231 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
231citing papers in PubMed, 14 pooled it
24.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04823507 completednot on this mapstarted 2021, after this paper: background citation

Photobiomodulation for Concussions: the Use of the ImPACT® Test to Assess Improvement in Cognition and Symptomatology

TypeobservationalSponsorMeditech Rehabilitation CentreRan2021 to 2021Enrolled35ConditionsMild Traumatic Brain InjuryArmsBIOFLEX DUO+
NCT05072743 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Improvement in Sleep Symptomatology and Neurocognitive Function Using Photobiomodulation in Post-Concussion Patients With Sleep-Wake Disturbances

TypeinterventionalSponsorMichael ZitneyRan2021 to 2024Enrolled20ConditionsPost-Concussion Syndrome, Sleep DisorderArmsPhotobiomodulation Therapy
NCT07651787 narecruitingnot on this mapstarted 2025, after this paper: background citation

Neurovascular and Mitochondrial Mechanisms of Transcranial Photobiomodulation in Vascular Mild Cognitive Impairment

TypeinterventionalSponsorUniversity of OklahomaRan2025 to 2026Enrolled40ConditionsMild Cognitive Impairment (MCI), Amyloid PathologyArmsActive Vielight Neuro RX-Duo device -Active transcranial photobiomodulation, Sham Vielight Neuro RX-Duo device -Sham transcranial photobiomodulation
3 · Its place in the literature

Who cites it

231 citing papers in PubMed, 14 syntheses or guidelines pooled it, 499 citations in OpenAlex.

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  4. Transabdominal photobiomodulation applications: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
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  5. Transcranial laser therapy for acute ischaemic stroke.The Cochrane database of systematic reviews · 2025
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  12. Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis.Photobiomodulation, photomedicine, and laser surgery · 2023
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171 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Farzad SalehpourNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran. farzadsalehpour1988@gmail.com.
Javad MahmoudiNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
Farzin KamariNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
Saeed Sadigh-EteghadNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
Seyed Hossein RastaDepartment of Medical Physics, Tabriz University of Medical Sciences, Tabriz, Iran.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA. hamblin@helix.mgh.harvard.edu.ORCID http://orcid.org/0000-0001-6431-4605
Tabriz University of Medical Sciences · IRHarvard University · US

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological conditions. Red/NIR light is able to stimulate complex IV of the mitochondrial respiratory chain (cytochrome c oxidase) and increase ATP synthesis. Moreover, light absorption by ion channels results in release of Ca

Indexed as

Low-Level Light TherapyAnimalsApoptosisBrainDose-Response Relationship, RadiationHumansNeurogenesisOxidative StressBrain functionCortical neuronsDementiaDepressionLow-level laser therapyPhotobiomodulation therapyStrokeTraumatic brain injury

Identifiers

PMID29327206
PMCPMC6041198
OpenAlexW2783026431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.