ArticleAnnals of medicine and surgery (2012)2018
Impact of liver volume and liver function on posthepatectomy liver failure after portal vein embolization- A multivariable cohort analysis.
Article in Annals of medicine and surgery (2012), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A systematic review and meta-analysis of liver venous deprivation versus portal vein embolization before hepatectomy: future liver volume, postoperative outcomes, and oncological safety.Frontiers in medicine · 2023Pooled it
- Nationwide organ volume distributions and cross-sectional age-associated differences in abdominal CT from Japan.Japanese journal of radiology · 2026Article
- Sarcopenia does not affect total liver function measured using technetium-99m mebrofenin hepatobiliary scintigraphy.EJNMMI research · 2026Article
- Hospital Volume and Post-Hepatectomy Liver Failure After Major Hepatectomy.Journal of surgical oncology · 2026Article
- Article
- Functional Liver Imaging Score to Predict Clinically Significant PHLF for Hepatocellular Carcinoma After Resection.Journal of hepatocellular carcinoma · 2025Article
- Establishing the clinical relevance of grade A post-hepatectomy liver failure.Journal of surgical oncology · 2024Article
- Early postoperative decrease of skeletal muscle mass predicts recurrence and poor survival after surgical resection for perihilar cholangiocarcinoma.BMC cancer · 2022Article
- CT-Based Prediction of Liver Function and Post-PVE Hypertrophy Using an Artificial Neural Network.Journal of clinical medicine · 2021Article
- Portal vein embolization with ethylene-vinyl alcohol copolymer for contralateral lobe hypertrophy before liver resection: safety, feasibility and initial experience.Quantitative imaging in medicine and surgery · 2021Article
- Assessment of liver function reserve by photoacoustic tomography: a feasibility study.Biomedical optics express · 2020Article
- "Small-for-Flow" Syndrome: Concept Evolution.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Review
- Multimodality Management of Ruptured Large Hepatocellular Carcinoma and Its Recurrence: Rupture at Presentation Should Not Rupture Hope of Long-Term Survival.Surgery journal (New York, N.Y.) · 2020Article
- SURGICAL MANAGEMENT OF LARGE HEPATOCELLULAR CARCINOMA: THE FIRST SINGLE-CENTER STUDY FROM WESTERN INDIA.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2020Observational
- [Preconditioning of the liver].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019Review
- Resection for Klatskin tumors: technical complexities and results.Translational gastroenterology and hepatology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver failure remains a life-threatening complication after liver resection, and is difficult to predict preoperatively. This retrospective cohort study evaluated different preoperative factors in regard to their impact on posthepatectomy liver failure (PHLF) after extended liver resection and previous portal vein embolization (PVE).
methodsPatient characteristics, liver function and liver volumes of patients undergoing PVE and subsequent liver resection were analyzed. Liver function was determined by the LiMAx test (enzymatic capacity of cytochrome P450 1A2). Factors associated with the primary end point PHLF (according to ISGLS definition) were identified through multivariable analysis. Secondary end points were 30-day mortality and morbidity.
results95 patients received PVE, of which 64 patients underwent major liver resection. PHLF occurred in 7 patients (11%). Calculated postoperative liver function was significantly lower in patients with PHLF than in patients without PHLF (67 vs. 109 μg/kg/h; p = 0.01). Other factors associated with PHLF by univariable analysis were age, future liver remnant, MELD score, ASA score, renal insufficiency and heart insufficiency. By multivariable analysis, future liver remnant was the only factor significantly associated with PHLF (p = 0.03). Mortality and morbidity rates were 4.7% and 29.7% respectively.
conclusionFuture liver remnant is the only preoperative factor with a significant impact on PHLF. Assessment of preoperative liver function may additionally help identify patients at risk for PHLF.
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