ArticleMediterranean journal of hematology and infectious diseases2018
Detection of β-Thalassemia Carriers by Red Cell Parameters Obtained from Automatic Counters using Mathematical Formulas.
Article in Mediterranean journal of hematology and infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- The impact of the expression signatures of LncRNAs HBBP1 and XIST on the diagnostic significance of patients with β-Thalassemia.Annals of hematology · 2026Article
- Interpretable machine learning models for beta thalassemia prediction: an explainable AI approach for smart healthcare 5.0.Frontiers in medicine · 2025Article
- Diagnostic Performance of Red Blood Cell Indices in the Differential Diagnosis of Iron Deficiency Anemia and the Thalassemia Trait in Chile: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2024Article
- Support Vector Machine-Based Formula for Detecting Suspected α Thalassemia Carriers: A Path toward Universal Screening.International journal of molecular sciences · 2024Article
- Global Trends on β-Thalassemia Research Over 10 Years: A Bibliometric Analysis.International journal of general medicine · 2024Article
- New logarithm-based discrimination formula for differentiating thalassemia trait from iron deficiency anemia in pregnancy.BMC pregnancy and childbirth · 2023Article
- Prediction of [Formula: see text]-Thalassemia carriers using complete blood count features.Scientific reports · 2022Article
- A Novel Algorithm Using Cell Population Data (VCS Parameters) as a Screening Discriminant between Alpha and Beta Thalassemia Traits.Diagnostics (Basel, Switzerland) · 2021Article
- Challenges in Thalassemia Carrier Detection in a Low Resource Setting Area of Eastern Indonesia: the Use of Erythrocyte Indices.Mediterranean journal of hematology and infectious diseases · 2021Article
- Application of Bayesian Decision Tree in Hematology Research: Differential Diagnosis ofComputational and mathematical methods in medicine · 2021Article
- Red Cell Indices in Screening of Thalassemia Trait During Antenatal Period.Journal of obstetrics and gynaecology of India · 2020Article
- Diagnostic performance of hematological discrimination indices to discriminate between βeta thalassemia trait and iron deficiency anemia and using cluster analysis: Introducing two new indices tested in Iranian population.Scientific reports · 2019Article
- Formulas for the Detection β-Thalassemia Carriers Are Affected by Changes in Red Cell Parameters.Mediterranean journal of hematology and infectious diseases · 2018Article
- Screening for beta-thalassemia trait; applicability of red cell indices and parameters - A study in Sri Lanka.International journal of health sciencesArticle
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6 authors.
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Abstract
backgroundβ-thalassemia major is a severe disease with high morbidity. The world prevalence of carriers is around 1.5-7%. The present study aimed to find a reliable formula for detecting β-thalassemia carriers using an extensive database of more than 22,000 samples obtained from a homogeneous population of childbearing age women with 3161 (13.6%) of β-thalassemia carriers and to check previously published formulas.
methodsWe applied a mathematical method based on the support vector machine (SVM) algorithm in the search for a reliable formula that can differentiate between thalassemia carriers and non-carriers, including normal counts or counts suspected to belong to iron-deficient women.
resultsShine's formula and our SVM formula showed >98% sensitivity and >99.77% negative predictive value (NPV). All other published formulas gave inferior results.
conclusionsWe found a reliable formula that can be incorporated into any automatic blood counter to alert health providers to the possibility of a woman being a β-thalassemia carrier. A further simple hemoglobin characterization by HPLC analysis should be performed to confirm the diagnosis, and subsequent family studies should be carried out. Our SVM formula is currently limited to women of fertility age until further analysis in other groups can be performed.
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