Evidence map›Paper›PMID 29326801›Full record

ReviewMediterranean journal of hematology and infectious diseases2018

Waldenstrom's Macroglobulinemia: An Update.

Maddalena Mazzucchelli, Anna Maria Frustaci, Marina Deodato, Roberto Cairoli, Alessandra Tedeschi

Open access · goldAbstract readReview
In one paragraph

Review in Mediterranean journal of hematology and infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
  9. Understanding the Cryoglobulinemias.Current rheumatology reports · 2019
    Review
  10. Article
  11. Article
  12. Diagnosis of Waldenström macroglobulinemia.Proceedings (Baylor University. Medical Center) · 2019
    Article
  13. Diagnosis and Management of Oncologic Emergencies.The western journal of emergency medicine · 2019
    Review
  14. Article
  15. Response to Ibrutinib of a Refractory IgA Lymphoplasmacytic Lymphoma Carrying theMediterranean journal of hematology and infectious diseases · 2019
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maddalena MazzucchelliDepartment of Haematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano.
Anna Maria FrustaciDepartment of Haematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano.
Marina DeodatoDepartment of Haematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano.
Roberto CairoliDepartment of Haematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano.
Alessandra TedeschiDepartment of Haematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano.
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Waldenstrom Macroglobulinemia is a rare lymphoproliferative disorder with distinctive clinical features. Diagnostic and prognostic characterisation in WM significantly changed with the discovery of two molecular markers: MYD88 and CXCR4. Mutational status of these latter influences both clinical presentation and prognosis and demonstrated therapeutic implications. Treatment choice in Waldenstrom disease is strictly guided by patients age and characteristics, specific goals of therapy, the necessity for rapid disease control, the risk of treatment-related neuropathy, disease features, the risk of immunosuppression or secondary malignancies and potential for future autologous stem cell transplantation. The therapeutic landscape has expanded during the last years and the approval of ibrutinib, the first drug approved for Waldenstrom Macroglobulinemia, represents a significant step forward for a better management of the disease.

Indexed as

IbrutinibMacroglobulinemiaTreatment-related NeuropathyWaldenstrom Disease

Identifiers

PMID29326801
PMCPMC5760071
OpenAlexW2780670843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.