Evidence map›Paper›PMID 29326692›Full record

ArticleFrontiers in immunology2017

The Absence of NOD1 Enhances Killing of

Mark S Gresnigt, Martin Jaeger, R K Subbarao Malireddi, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Willem J G Melchers, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  5. Antifungal Innate Immunity.Advances in experimental medicine and biology · 2025
    Review
  6. NOD1: a metabolic modulator.Frontiers in endocrinology · 2024
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Aspergillus fumigatus and Aspergillosis in 2019.Clinical microbiology reviews · 2019
    Review
  14. Review
  15. Pattern recognition receptors in fungal immunity.Seminars in cell & developmental biology · 2019
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Mark S GresnigtUnité de recherche Cytokines and Inflammation, Institut Pasteur, Paris, France.
Martin JaegerLaboratory for Experimental Internal Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
R K Subbarao MalireddiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, United States.
Orhan RasidUnité de recherche Cytokines and Inflammation, Institut Pasteur, Paris, France.
Grégory JouvionUnité Histopathologie Humaine et Modèles Animaux, Département Infection et Epidémiologie, Institut Pasteur, Paris, France.
Catherine FittingUnité de recherche Cytokines and Inflammation, Institut Pasteur, Paris, France.
Willem J G MelchersDepartment of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.
Thirumala-Devi KannegantiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, United States.
Agostinho CarvalhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Oumaima Ibrahim-GranetUnité de recherche Cytokines and Inflammation, Institut Pasteur, Paris, France.
Frank L van de VeerdonkLaboratory for Experimental Internal Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Institut Pasteur · FRRadboud University Medical Center · NLRadboud University Nijmegen · NLSt. Jude Children's Research Hospital · USUniversity of Minho · PT

Funding

Role of NLR Inflammasomes in Autoinflammatory Diseases and Host DefenseR01AR056296 · NIAMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2008 to 2022
$5.9M
The Non-Inflammasome NLRs in Immunity and Host defenseR01AI124346 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2016 to 2026
$5.8M
Inflammatory Caspases in Innate Immunity and InflammationR37AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2017 to 2026
$4.9M
NLR signaling in colitis and colorectal tumorigenesisR01CA163507 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2020
$3.5M
Inflammatory Caspases in Innate Immunity and InflammationR01AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2016
$2.2M
NCI NIH HHS R01 CA163507NIAID NIH HHS R01 AI101935NIAID NIH HHS R01 AI124346NIAID NIH HHS R37 AI101935NIAMS NIH HHS R01 AR056296
6 · The paper itself

Abstract

One of the major life-threatening infections for which severely immunocompromised patients are at risk is invasive aspergillosis (IA). Despite the current treatment options, the increasing antifungal resistance and poor outcome highlight the need for novel therapeutic strategies to improve outcome of patients with IA. In the current study, we investigated whether and how the intracellular pattern recognition receptor NOD1 is involved in host defense against

Indexed as

Aspergillus fumigatusdectin-1fungal killingNOD1nucleotide-binding oligomerization domain

Identifiers

PMID29326692
PMCPMC5733348
OpenAlexW2772279356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.