ReviewFrontiers in neurology2017
Non-24-Hour Sleep-Wake Rhythm Disorder in the Totally Blind: Diagnosis and Management.
Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 69 citations in OpenAlex.
- Sensory Deprivation and the Brain: Neurobiological Mechanisms, Psychological Effects, and Clinical Implications.Brain sciences · 2026Review
- Visual impairment, age-related eye disease, and sleep dysfunction in older adults.Eye (London, England) · 2025Article
- The Sleep-Wake Cycle Pattern of a Blind Trail Ultramarathon Runner and His Guide: The World's First Case.Clocks & sleep · 2025Article
- The Role of Season, Sunlight, and Light Sensitivity in Self-Reported Depressive Symptoms by Adults With Visual Impairment.Translational vision science & technology · 2024Article
- Article
- The Effect of Blindness on Biological Rhythms and the Consequences of Circadian Rhythm Disorder.Turkish journal of ophthalmology · 2023Article
- Ontogenetic variations of proteins in neurons of the lateral preoptic nucleus of rats' hypothalamus under a modified light regime.Journal of medicine and life · 2023Article
- The Complex Effects of Light on Metabolism in Humans.Nutrients · 2023Review
- Case report: Diagnosis and intervention of a non-24-h sleep-wake disorder in a sighted child with a psychiatric disorder.Frontiers in psychiatry · 2023Article
- Keep Your Mask On: The Benefits of Masking for Behavior and the Contributions of Aging and Disease on Dysfunctional Masking Pathways.Frontiers in neuroscience · 2022Review
- Circadian rhythms in diabetic retinopathy: an overview of pathogenesis and investigational drugs.Expert opinion on investigational drugs · 2020Review
- Non-24-hour sleep-wake disorder successfully treated with the combination of ramelteon and suvorexant in a case of autism spectrum disorder.Neuropsychopharmacology reports · 2020Article
- Children's Health in the Digital Age.International journal of environmental research and public health · 2020Review
- Sleep-Related Disorders in Neurology and Psychiatry.Deutsches Arzteblatt international · 2019Review
- Working against the biological clock: a review for the Occupational Physician.Industrial health · 2019Review
- Understanding Quantitative Circadian Regulations Are Crucial Towards Advancing Chronotherapy.Cells · 2019Review
- Circadian Rhythm Disturbances in the Blind.Current neurology and neuroscience reports · 2018Review
- Health risks associated with genetic alterations in internal clock system by external factors.International journal of biological sciences · 2018Review
- Basic chronobiology: what do sleep physicians need to know?Sleep science (Sao Paulo, Brazil)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several aspects of human physiology and behavior are dominated by 24-h circadian rhythms with key impacts on health and well-being. These include mainly the sleep-wake cycle, vigilance and performance patterns, and some hormone secretions. The rhythms are generated spontaneously by an internal "pacemaker," the suprachiasmatic nuclei within the anterior hypothalamus. This master clock has, for most humans, an intrinsic rhythm slightly longer than 24 h. Daily retinal light exposure is necessary for the synchronization of the circadian rhythms with the external 24-h solar environment. This daily synchronization process generally poses no problems for sighted individuals except in the context of jetlag or working night shifts being conditions of circadian desynchrony. However, many blind subjects with no light perception had periodical circadian desynchrony, in the absence of light information to the master clock leading to poor circadian rhythm synchronization. Affected patients experience cyclical or periodic episodes of poor sleep and daytime dysfunction, severely interfering with social, academic, and professional life. The diagnosis of Non-24 Sleep-Wake Rhythm Disorder, also named free-running disorder, non-entrained disorder, or hypernycthemeral syndrome, remains challenging from a clinical point of view due to the cyclical symptoms and should be confirmed by measurements of circadian biomarkers such as urinary melatonin to demonstrate a circadian period outside the normal range. Management includes behavioral modification and melatonin. Tasimelteon, a novel melatonin receptor 1 and 2 agonist, has demonstrated its effectiveness and safety with an evening dose of 20 mg and is currently the only treatment approved by the FDA and the European Medicines Agency.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.