ArticleFrontiers in pharmacology2017
A Combined LC-MS Metabolomics- and 16S rRNA Sequencing Platform to Assess Interactions between Herbal Medicinal Products and Human Gut Bacteria
Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Global research trends and hotspots of plant physiologically active substances: quantitative visualization analysis based on CiteSpace.Plant biology (Stuttgart, Germany) · 2026Article
- Rapid biotransformation of STW 5 constituents by human gut microbiome from IBS- and non-IBS donors.Microbiology spectrum · 2024Article
- Regulation of Gut Microbiota by Herbal Medicines.Current drug metabolism · 2024Review
- In Vitro Biotransformation and Anti-Inflammatory Activity of Constituents and Metabolites ofPharmaceutics · 2023Article
- Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology.Pharmaceutical biology · 2022Article
- A conversation between hyphenated spectroscopic techniques and phytometabolites from medicinal plants.Analytical science advances · 2021Review
- Heat Stress in Broiler Chickens and the Effect of Dietary Polyphenols, with Special Reference to Willow (Antioxidants (Basel, Switzerland) · 2021Review
- Korean Traditional Medicine (Metabolites · 2019Article
- The Anti-depression Effect of Angelicae Sinensis Radix Is Related to the Pharmacological Activity of Modulating the Hematological Anomalies.Frontiers in pharmacology · 2019Article
- Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis.World journal of gastroenterology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herbal preparations are complex mixtures of natural products, many of which are able to reach the distal gut due to low oral bioavailability. There, they can influence the microbial communities, and can be metabolized into potentially absorbable bioactive compounds by the intestinal bacteria. This aspect has often been disregarded when searching for the active principles of medicinal plants and herbal medicinal products. The aim of this study was to establish an interdisciplinary platform to unravel interactions of herbal medicine and intestinal microbiota, using a combined LC-MS metabolomics and 16S rRNA microbiome sequencing approach. Willow bark extract (WBE), a herbal medicinal product with a long history of traditional use and a well-established anti-inflammatory activity, was incubated with human fecal suspension under anoxic conditions. Samples were taken after 0.5, 4, and 24 h of incubation. Microbiome analyses revealed that incubation with WBE had a marked effect on microbial community composition and functions. For example, the proportion of
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Registered trials
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