Evidence map›Paper›PMID 29326336›Full record

ArticleGenes & development2017

ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.

Wei Zhong Leong, Shi Hao Tan, Phuong Cao Thi Ngoc, Stella Amanda, Alice Wei Yee Yam, Wei-Siang Liau, Zhiyuan Gong, Lee N Lawton, Daniel G Tenen, Takaomi Sanda

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
  3. Genetic susceptibility ofGlobal medical genetics · 2025
    Article
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  5. Review
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  8. Article
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  11. Article
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  13. Article
  14. Article
  15. Cell genomics · 2023
    Article
  16. IKAROS in Acute Leukemia: A Positive Influencer or a Mean Hater?International journal of molecular sciences · 2023
    Review
  17. Article
  18. Haematologica · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Wei Zhong LeongCancer Science Institute of Singapore, National University of Singapore, 117599 Singapore.
Shi Hao TanCancer Science Institute of Singapore, National University of Singapore, 117599 Singapore.
Phuong Cao Thi NgocCancer Science Institute of Singapore, National University of Singapore, 117599 Singapore.
Stella AmandaCancer Science Institute of Singapore, National University of Singapore, 117599 Singapore.
Alice Wei Yee YamCancer Science Institute of Singapore, National University of Singapore, 117599 Singapore.
Wei-Siang LiauCancer Science Institute of Singapore, National University of Singapore, 117599 Singapore.
Zhiyuan GongDepartment of Biological Sciences, National University of Singapore, 117543 Singapore.
Lee N LawtonCancer Science Institute of Singapore, National University of Singapore, 117599 Singapore.
Daniel G TenenCancer Science Institute of Singapore, National University of Singapore, 117599 Singapore.
Takaomi SandaCancer Science Institute of Singapore, National University of Singapore, 117599 Singapore.ORCID 0000-0003-1621-4954
National University of Singapore · SGHarvard University · US

Funding

TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5M
Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DANIEL G TENEN · 2017 to 2026
$24.6M
Mechanisms of regulation by RNA in acute myeloid leukemiaR35CA197697 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TENEN, DANIEL G · 2015 to 2021
$7.1M
Pathway Dependence on Tyrosine Kinase TYK2 in T-cell Acute Lymphoblastic LeukemiaK99CA157951 · NCI · DANA-FARBER CANCER INST · PI SANDA, TAKAOMI · 2011 to 2012
$275k
NCI NIH HHS K99 CA157951NCI NIH HHS P01 CA066996NCI NIH HHS R35 CA197697NHLBI NIH HHS P01 HL131477
6 · The paper itself

Abstract

The oncogenic transcription factor

Indexed as

Gene Expression Regulation, NeoplasticAnimalsCarcinogenesisCell Line, TumorCell SurvivalDNA-Binding ProteinsEnhancer Elements, GeneticGene Expression ProfilingGenes, mycHEK293 CellsHumansPrecursor T-Cell Lymphoblastic Leukemia-LymphomaProtein BindingProtein DomainsT-Cell Acute Lymphocytic Leukemia Protein 1ThymocytesARID5B protein, humanDNA-Binding ProteinsTAL1 protein, humanT-Cell Acute Lymphocytic Leukemia Protein 1Transcription FactorsARID5Bcore regulatory circuitMYCTAL1T-cell acute lymphoblastic leukemia

Identifiers

PMID29326336
PMCPMC5795782
OpenAlexW2782611496

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.