ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018
RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells.
Abstract read
In one paragraph
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- A systematic review of recommendations on screening strategies for breast cancer due to hereditary predisposition: Who, When, and How?Cancer medicine · 2021Pooled it
- Review
- RNF126 Promotes Ovarian Cancer Progression by Reprogramming Lipid Metabolism Through Degradation of ACAP2.Biochemical genetics · 2026Article
- RNF126 writes a non-canonical ubiquitin code on midnolin to tune protein stability.Acta biochimica et biophysica Sinica · 2026Article
- Ring-finger protein RNF126 promotes prostate cancer progression via regulation of MBNL1.Scientific reports · 2025Article
- Multi-Omics and Experimental Validation Reveal Anti-HCC Mechanisms of Tibetan Liuwei Muxiang Pill and Quercetin.Pharmaceuticals (Basel, Switzerland) · 2025Article
- The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity.Nature communications · 2024Article
- Multi-omics characterization of esophageal squamous cell carcinoma identifies molecular subtypes and therapeutic targets.JCI insight · 2024Article
- LowTheranostics · 2024Article
- Potential Therapeutic Targets in Triple-Negative Breast Cancer Based on Gene Regulatory Network Analysis: A Comprehensive Systems Biology Approach.International journal of breast cancer · 2024Article
- Ubiquitin E3 ligases in cancer: somatic mutation and amplification.BMB reports · 2023Review
- RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Ring finger protein 126 promotes breast cancer metastasis and serves as a potential target to improve the therapeutic sensitivity of ATR inhibitors.Breast cancer research : BCR · 2022Article
- RNF126 contributes to stem cell-like properties and metastasis in hepatocellular carcinoma through ubiquitination and degradation of LKB1.Human cell · 2022Article
- Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity.Epigenetics & chromatin · 2022Article
- Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy.Cancer research · 2022Article
- A Novel Role for RNF126 in the Promotion of G2 Arrest via Interaction With 14-3-3σ.International journal of radiation oncology, biology, physics · 2022Article
- Identification of Molecular Markers Related to Immune Infiltration in Patients with Severe Asthma: A Comprehensive Bioinformatics Analysis Based on the Human Bronchial Epithelial Transcriptome.Disease markers · 2022Article
- Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.ACS chemical biology · 2021Article
- Ring finger protein 126: a potential biomarker for colorectal cancer.Histology and histopathology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 1 institution in 1 country.
Xiaosong Yang *Department of Radiation Oncology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
You Pan *Department of Radiation Oncology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Zhaojun QiuDepartment of Radiation Oncology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Zhanwen DuDepartment of Radiation Oncology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Yao ZhangDepartment of Radiation Oncology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Pengyan FaDepartment of Radiation Oncology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Shashank GorityalaDepartment of Chemistry, Cleveland State University, Cleveland, Ohio.
Shanhuai MaDepartment of Radiation Oncology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Shunqiang LiDivision of Oncology Breast Oncology Section, Washington University Medical School, St. Louis, Missouri.
Ceshi ChenKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China.
Hongbing WangDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland.
Yan XuDepartment of Chemistry, Cleveland State University, Cleveland, Ohio.
Chunhong YanGeorgia Cancer Center, Augusta University, Augusta, Georgia.
Keri RuthCase Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Zhefu MaDepartment of Breast Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Zhang.9543@osu.edu mazhefu@mail.sysu.edu.cn.
Junran ZhangDepartment of Radiation Oncology, School of Medicine, Case Western Reserve University, Cleveland, Ohio. Zhang.9543@osu.edu mazhefu@mail.sysu.edu.cn.
Cleveland State University · US
Funding
TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MTHE ROLE OF NEDD4-1 IN IGF-1R SIGNALINGR01CA154625 · NCI · WASHINGTON UNIVERSITY · PI ZHANG, JUNRAN · 2011 to 2016
$1.6MFunction and Regulation of SLC13A5 in the LiverR01GM121550 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, HONGBING · 2018 to 2021
$1.3MThe Role of ATF3 in the DNA Damage ResponseR01CA139107 · NCI · AUGUSTA UNIVERSITY · PI YAN, CHUNHONG · 2010 to 2015
$1.2MRole of constitutive androstane receptor in cyclophosphamide-based chemotherapyR01GM107058 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, HONGBING · 2013 to 2016
$1.2MNCI NIH HHS P30 CA016058NCI NIH HHS P30 CA043703NCI NIH HHS R01 CA139107NCI NIH HHS R01 CA154625NIGMS NIH HHS R01 GM107058NIGMS NIH HHS R01 GM121550
Abstract
PubMed holds no abstract for this paper.
Indexed as
Biomarkers, TumorBreast NeoplasmsCell Line, TumorCheckpoint Kinase 1Cohort StudiesDNA ReplicationFemaleHumansImmunohistochemistryMCF-7 CellsPrognosisPromoter Regions, GeneticRetrospective StudiesUbiquitin-Protein LigasesBiomarkers, TumorCheckpoint Kinase 1CHEK1 protein, humanRNF126 protein, humanUbiquitin-Protein Ligases
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.