Evidence map›Paper›PMID 29326275›Full record

ArticleScience (New York, N.Y.)2018

CX3CR1

Irina Leonardi, Xin Li, Alexa Semon, Dalin Li, Itai Doron, Gregory Putzel, Agnieszka Bar, Daniel Prieto, Maria Rescigno, Dermot P B McGovern and 2 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. AbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Effect of the intestinal microbiota on TSeminars in immunopathology · 2026
    Review
  11. Maintenance of intestinal CX3CR1Nature communications · 2026
    Article
  12. Article
  13. Article
  14. Yeasts in the gastrointestinal tract.FEMS yeast research · 2026
    Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Irina LeonardiGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-0369-7371
Xin LiGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-9444-8214
Alexa SemonGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-0551-1446
Dalin LiThe F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0003-4738-0074
Itai DoronGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0001-6855-2977
Gregory PutzelThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY 10021, USA.
Agnieszka BarGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-4037-1370
Daniel PrietoFaculty of Pharmacy, Department of Microbiology II, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0003-3931-5790
Maria RescignoDepartment of Experimental Oncology, European Institute of Oncology, I-20141 Milan, Italy.
Dermot P B McGovernThe F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Jesus PlaFaculty of Pharmacy, Department of Microbiology II, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0003-0897-1963
Iliyan D IlievGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0003-0884-9749

Funding

Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1M
Utilizing the Phenomics of IBD to Enhance Gene DiscoveryU01DK062413 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Dermot Patrick McGovern · 2002 to 2026
$12.2M
Commensal fungal communities in the regulation of immunity and intestinal inflammation.R01DK113136 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIYAN Dimitrov ILIEV · 2017 to 2026
$4.2M
Mechanisms of Protection by Commensal Fungi in ColitisR00DK098310 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2016 to 2018
$729k
Impact of immunosuppression therapy on commensal fungi and intestinal diseaseR21AI123819 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2016 to 2017
$466k
Mechanisms of Protection by Commensal Fungi in ColitisK99DK098310 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI ILIEV, ILIYAN DIMITROV · 2014 to 2015
$180k
NIAID NIH HHS R21 AI123819NIDDK NIH HHS K99 DK098310NIDDK NIH HHS P01 DK046763NIDDK NIH HHS R00 DK098310NIDDK NIH HHS R01 DK113136NIDDK NIH HHS U01 DK062413
6 · The paper itself

Abstract

Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and inflammatory disease. Nonetheless, the mechanisms governing immunity to gut fungal communities (mycobiota) remain unknown. We identified CX3CR1

Indexed as

AnimalsAntibodies, FungalCandida albicansColitisCrohn DiseaseCX3C Chemokine Receptor 1Dendritic CellsGastrointestinal MicrobiomeHumansImmunity, MucosalImmunoglobulin GIntestinesMiceMutation, MissenseMycobiomePhagocytesAntibodies, FungalCX3C Chemokine Receptor 1CX3CR1 protein, humanCx3cr1 protein, mouseImmunoglobulin G

Identifiers

PMID29326275
PMCPMC5805464

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.