ArticleScience (New York, N.Y.)2018
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
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Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers.
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161citing papers in PubMed
28.7field-weighted citation impact, top 1% of its field
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Who cites it
161 citing papers in PubMed, 270 citations in OpenAlex.
- Genome-Wide Analysis of the Malaria ParasiteFrontiers in immunology · 2020Trial
- Dual plasmepsin IX and X inhibitors are refractory to development of resistance.PLoS pathogens · 2026Article
- Identification of genetic markers of quinine partial resistance in Plasmodium falciparum.Nature microbiology · 2026Article
- Antimalarial cytoskeletal targeting with broad apicomplexan activity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Potent reaction hijacking inhibitors ofbioRxiv : the preprint server for biology · 2026Article
- Segmental copy number amplifications are more stable than aneuploidies in the absence of selection.Molecular biology and evolution · 2026Article
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- Genomic Plasticity and Molecular Mechanisms of Antimalarial Drug Resistance in Plasmodium falciparum: Implications for Treatment Failure and Genomic Surveillance.BioMed research international · 2026Review
- Molecular mechanisms underlying drug resistance in protozoan parasites: emerging mechanisms and therapeutic perspectives.Frontiers in parasitology · 2026Review
- Characterization of β-Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced DormantACS infectious diseases · 2025Article
- Disruption of P. falciparum amino acid transporter elevates intracellular proline and induces resistance to Prolyl-tRNA synthetase inhibitors.Cell chemical biology · 2025Article
- Identification of α-Azacyclic Acetamide-Based Inhibitors ofACS infectious diseases · 2025Article
- PfATP2 is a flippase on the Plasmodium falciparum surface that is important for growth and influences parasite sensitivity to antiplasmodial compounds.PLoS pathogens · 2025Article
- Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity.Cell chemical biology · 2025Article
- Tracking Plasmodium falciparum antimalarial resistance markers during a malaria pre-elimination period in the Pacific coast of South America.Scientific reports · 2025Article
- Small-molecule screen in C. elegans identifies benzenesulfonamides as inhibitors of microsporidia spores.npj antimicrobials and resistance · 2025Article
- Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium.PLoS pathogens · 2025Article
- Predicting Plasmodium drug resistance through in vitro evolution.Trends in parasitology · 2025Article
- Aqueous extract of Enantia chlorantha Oliv. demonstrates antimalarial activity and improves redox imbalance and biochemical alterations in mice.BMC complementary medicine and therapies · 2025Article
101 more citing papers are in PubMed but not listed here.
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Authors and funding
44 authors at 11 institutions in 5 countries.
Annie N CowellSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0002-7964-6220
Eva S IstvanDepartments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8666-3248
Amanda K LukensDepartment of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0002-9560-7643
Maria G Gomez-LorenzoTres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain.ORCID 0000-0003-2065-1145
Manu VanaerschotDepartment of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.ORCID 0000-0002-9141-2347
Tomoyo Sakata-KatoDepartment of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Erika L FlannerySchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.
Pamela MagistradoDepartment of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Edward OwenDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Matthew AbrahamSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0003-0272-4443
Gregory LaMonteSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.
Heather J PainterDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Roy M WilliamsSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0002-5442-9166
Virginia FrancoTres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain.
Maria LinaresTres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain.ORCID 0000-0003-3180-6560
Ignacio ArriagaTres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain.
Selina BoppDepartment of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0002-9412-9766
Victoria C CoreySchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.
Nina F GnädigDepartment of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.ORCID 0000-0002-8104-7032
Olivia Coburn-FlynnDepartment of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Christin ReimerSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.
Purva GuptaSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.
James M MurithiDepartment of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.ORCID 0000-0003-0741-8461
Pedro A MouraDepartment of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Olivia FuchsSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0002-1572-2685
Erika SasakiSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0002-1386-0179
Sang W KimSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.
Christine H TengSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.
Lawrence T WangSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.
Aslı AkidilMalaria Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
Sophie AdjalleyMalaria Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
Paul A WillisMedicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland.
Dionicio SiegelSkaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Olga TanaseichukGenomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.ORCID 0000-0002-7733-9972
Yang ZhongGenomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.
Yingyao ZhouGenomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.
Manuel LlinásDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-6173-5882
Sabine OttilieSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.
Francisco-Javier GamoTres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain.
Marcus C S LeeDepartment of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.ORCID 0000-0002-4973-0915
Daniel E GoldbergDepartments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-3529-8399
David A FidockDepartment of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.ORCID 0000-0001-6753-8938
Dyann F WirthDepartment of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0002-8604-4455
Elizabeth A WinzelerSchool of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. ewinzeler@ucsd.edu.ORCID 0000-0002-4049-2113
University of California San Diego · USColumbia University · USGlaxoSmithKline (France) · FRGenomics Institute of the Novartis Research Foundation · USHarvard University · USPennsylvania State University · USWellcome Sanger Institute · GBBroad Institute · USWashington University in St. Louis · USMedicines for Malaria Venture · CHUniversity of Montana · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3MSYNTHETIC SYSTEMSP50GM085764 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2010 to 2018
$23.3MRESEARCH IN INFECTIOUS DISEASEST32AI007036 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 1985 to 2025
$9.2MTraining Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6MRole of pfcrt in chloroquine resistance in P. falciparumR01AI050234 · NIAID · YESHIVA UNIVERSITY · PI FIDOCK, DAVID A · 2001 to 2015
$5.7MNovel Genetic Mechanism of Artemisinin Resistance for MalariaR01AI099105 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI HARTL, DANIEL L, WIRTH, DYANN F · 2013 to 2021
$5.4MDefining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug ResistanceR37AI050234 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2018 to 2026
$4.4MDiscovery of chemically validated malaria liver stage targetsR01AI090141 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2011 to 2019
$3.4MDefining the targets of broad intervention antimalarial agentsR01AI103058 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2013 to 2016
$2.6MIdentifaction of the genetic basis of primaquine resistance in malaria parasitesF32AI102567 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FLANNERY, ERIKA LEA · 2013 to 2015
$159kNIAID NIH HHS F32 AI102567NIAID NIH HHS R01 AI050234NIAID NIH HHS R01 AI090141NIAID NIH HHS R01 AI103058NIAID NIH HHS R37 AI050234NIAID NIH HHS T32 AI007036NIGMS NIH HHS P50 GM085764NIGMS NIH HHS T32 GM007198NIGMS NIH HHS T32 GM008666
Abstract
Chemogenetic characterization through in vitro evolution combined with whole-genome analysis can identify antimalarial drug targets and drug-resistance genes. We performed a genome analysis of 262
Indexed as
Genome, ProtozoanActivation, MetabolicAllelesAntimalarialsDirected Molecular EvolutionDNA Copy Number VariationsDrug ResistanceDrug Resistance, MultipleGenes, ProtozoanMetabolomicsMutationPlasmodium falciparumSelection, GeneticTranscription FactorsAntimalarialsTranscription Factors
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