Evidence map›Paper›PMID 29326169›Full record

ArticleThe Journal of biological chemistry2018

Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.

Michael C Goodman, Shu Xu, Carol A Rouzer, Surajit Banerjee, Kebreab Ghebreselasie, Marco Migliore, Daniele Piomelli, Lawrence J Marnett

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Exploiting the 2-(1,3,4,9-tetrahydropyrano[3,4-Journal of medicinal chemistry · 2025
    Article
  3. Review
  4. Design, synthesis andJournal of enzyme inhibition and medicinal chemistry · 2021
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Potential of Endocannabinoids to Control Bladder Pain.Frontiers in systems neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Michael C GoodmanFrom the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology and Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Shu XuFrom the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology and Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Carol A RouzerFrom the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology and Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Surajit Banerjeethe Northeastern Collaborative Access Team, Argonne National Laboratory, Argonne, Illinois 60439.
Kebreab GhebreselasieFrom the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology and Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Marco Migliorethe Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, 16163 Genoa, Italy.
Daniele Piomellithe Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, 16163 Genoa, Italy.
Lawrence J MarnettFrom the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology and Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, larry.marnett@vanderbilt.edu.
Vanderbilt University · USItalian Institute of Technology · ITArgonne National Laboratory · US

Funding

Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
FUNCTIONAL ANALYSIS OF CYCLOOXYGENASE 2R01CA089450 · NCI · VANDERBILT UNIVERSITY · PI MARNETT, LAWRENCE J. · 2001 to 2016
$6.3M
MECHANISM OF ACTION OF GLUTATHIONE S-TRANSFERASER01GM030910 · NIGMS · VANDERBILT UNIVERSITY · PI SANDERS, CHARLES R · 1985 to 2016
$4.7M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
NCI NIH HHS R01 CA089450NIGMS NIH HHS P41 GM103403NIGMS NIH HHS R01 GM030910NIH HHS S10 OD021527
6 · The paper itself

Abstract

The cyclooxygenases COX-1 and COX-2 oxygenate arachidonic acid (AA) to prostaglandin H

Indexed as

Catalytic DomainAmidohydrolasesCyclooxygenase InhibitorsFatty Acid Amide HydrolasesIsoenzymesPhenylcarbamatesPhenylpropionatesProstaglandin-Endoperoxide SynthasesProtein BindingStereoisomerismSubstrate SpecificityAmidohydrolasesARN2508Cyclooxygenase InhibitorsFatty Acid Amide HydrolasesIsoenzymesPhenylcarbamatesPhenylpropionatesProstaglandin-Endoperoxide Synthasescyclooxygenase (COX)enzyme catalysisenzyme inhibitorenzyme kineticsenzyme structurefatty acid metabolisminflammationpolyunsaturated fatty acid (PUFA)

Identifiers

PMID29326169
PMCPMC5836124
OpenAlexW2783503367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.