Evidence map›Paper›PMID 29326168›Full record

ArticleThe Journal of biological chemistry2018

Cyclic di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation in

Merve S Zeden, Christopher F Schuster, Lisa Bowman, Qiyun Zhong, Huw D Williams, Angelika Gründling

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 106 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. A c-di-AMP-controlled glutamine synthesis pathway promotes persistence ofbioRxiv : the preprint server for biology · 2026
    Article
  5. mBio · 2026
    Article
  6. Article
  7. Article
  8. bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. Regulation of potassium homeostasis inFrontiers in microbiology · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Biofilm formation byProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. The role ofJournal of bacteriology · 2024
    Article
  19. Article
  20. Bacterial cell volume regulation and the importance of cyclic di-AMP.Microbiology and molecular biology reviews : MMBR · 2024
    Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Merve S ZedenFrom the Section of Microbiology and Medical Research Council Centre for Molecular Bacteriology and Infection and.
Christopher F SchusterFrom the Section of Microbiology and Medical Research Council Centre for Molecular Bacteriology and Infection and.ORCID 0000-0002-4566-7226
Lisa BowmanFrom the Section of Microbiology and Medical Research Council Centre for Molecular Bacteriology and Infection and.
Qiyun ZhongFrom the Section of Microbiology and Medical Research Council Centre for Molecular Bacteriology and Infection and.
Huw D WilliamsDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Angelika GründlingFrom the Section of Microbiology and Medical Research Council Centre for Molecular Bacteriology and Infection and a.grundling@imperial.ac.uk.ORCID 0000-0002-6235-8687
Imperial College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L024209/1European Research Council 260371Medical Research Council MR/P028225/1Wellcome Trust 100289
6 · The paper itself

Abstract

Cyclic di-adenosine monophosphate (c-di-AMP) is a recently discovered signaling molecule important for the survival of Firmicutes, a large bacterial group that includes notable pathogens such as

Indexed as

Microbial ViabilityOsmosisAmino Acids, CyclicAnaerobiosisBacterial ProteinsBetaineCell SizeMembrane PotentialsMutationReactive Oxygen SpeciesStaphylococcus aureusAmino Acids, CyclicBacterial ProteinsBetaineReactive Oxygen Speciescyclic diadenosine monophosphate (c-di-AMP)osmotic swellingrespirationsignalingStaphylococcus aureus (S. aureus)

Identifiers

PMID29326168
PMCPMC5836111
OpenAlexW2767464609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.