Evidence map›Paper›PMID 29326163›Full record

ArticleThe Journal of biological chemistry2018

LIM and cysteine-rich domains 1 is required for thrombin-induced smooth muscle cell proliferation and promotes atherogenesis.

Jagadeesh Janjanam, Baolin Zhang, Arul M Mani, Nikhlesh K Singh, James G Traylor, A Wayne Orr, Gadiparthi N Rao

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jagadeesh JanjanamFrom the Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163 and.
Baolin ZhangFrom the Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163 and.
Arul M ManiFrom the Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163 and.
Nikhlesh K SinghFrom the Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163 and.
James G Traylorthe Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103.
A Wayne Orrthe Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103.
Gadiparthi N RaoFrom the Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163 and rgadipar@uthsc.edu.
University of Tennessee Health Science Center · USLouisiana State University Health Sciences Center Shreveport · US

Funding

NFATs AND VASCULAR INJURYR01HL069908 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI RAO, GADIPARTHI N · 2002 to 2019
$5.9M
GPCR Signaling & Vascular Wall RemodelingR01HL103575 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI RAO, GADIPARTHI N · 2011 to 2019
$4.1M
Nck Adaptor Proteins in Atherogenic Endothelial ActivationR01HL133497 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ORR, ANTHONY WAYNE · 2016 to 2024
$3.8M
Matrix Signaling in Endothelial Cell DysfunctionR01HL098435 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ORR, ANTHONY WAYNE · 2010 to 2020
$3.2M
NHLBI NIH HHS R01 HL069908NHLBI NIH HHS R01 HL098435NHLBI NIH HHS R01 HL103575NHLBI NIH HHS R01 HL133497
6 · The paper itself

Abstract

Restenosis arises after vascular injury and is characterized by arterial wall thickening and decreased arterial lumen space. Vascular injury induces the production of thrombin, which in addition to its role in blood clotting acts as a mitogenic and chemotactic factor. In exploring the molecular mechanisms underlying restenosis, here we identified

Indexed as

AdultAgedAnimalsAtherosclerosisCo-Repressor ProteinsFemaleHumansLIM Domain ProteinsMaleMiceMiddle AgedMyocytes, Smooth MuscleRatsThrombinYoung AdultCo-Repressor ProteinsLIM Domain ProteinsLMCD1 protein, humanThrombinatherosclerosiscell proliferationsignal transductionvascular biologyvascular smooth muscle cells

Identifiers

PMID29326163
PMCPMC5836108
OpenAlexW2784237670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.