ArticleJournal of the American Society of Nephrology : JASN2018
Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion.
Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect.Andrology · 2019Pooled it
- Ureter development and associated congenital anomalies.Nature reviews. Nephrology · 2025Review
- Identification and functional characteristics of CHD1L gene variants implicated in human Müllerian duct anomalies.Biological research · 2024Article
- Gene expression detection in developing mouse tissue using in situ hybridization and µCT imaging.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- "Hypothesis: Patient with possible disturbance in programmed cell death": further insights in pathogenicity and clinical features of Fraser syndrome.European journal of human genetics : EJHG · 2023Article
- Won't You be My Neighbor: How Epithelial Cells Connect Together to Build Global Tissue Polarity.Frontiers in cell and developmental biology · 2022Review
- Intrauterine Low-Protein Diet Exacerbates Abnormal Development of the Urinary System inKidney diseases (Basel, Switzerland) · 2021Article
- Three-Dimensional X-ray Imaging of β-Galactosidase Reporter Activity by Micro-CT: Implication for Quantitative Analysis of Gene Expression.Brain sciences · 2021Article
- Renin-angiotensin system in mammalian kidney development.Pediatric nephrology (Berlin, Germany) · 2021Review
- Assaying three-dimensional cellular architecture using X-ray tomographic and correlated imaging approaches.The Journal of biological chemistry · 2020Review
- Duplex kidney formation: developmental mechanisms and genetic predisposition.F1000Research · 2020Review
- A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys.Nature communications · 2019Article
- Developmental pathology of congenital kidney and urinary tract anomalies.Clinical kidney journal · 2019Article
- The development of the cloaca in the human embryo.Journal of anatomy · 2018Article
- Estrogens and development of the rete testis, efferent ductules, epididymis and vas deferens.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The epithelial Wolffian duct (WD) inserts into the cloaca (primitive bladder) before metanephric kidney development, thereby establishing the initial plumbing for eventual joining of the ureters and bladder. Defects in this process cause common anomalies in the spectrum of congenital anomalies of the kidney and urinary tract (CAKUT). However, developmental, cellular, and molecular mechanisms of WD-cloaca fusion are poorly understood. Through systematic analysis of early WD tip development in mice, we discovered that a novel process of spatiotemporally regulated apoptosis in WD and cloaca was necessary for WD-cloaca fusion. Aberrant RET tyrosine kinase signaling through tyrosine (Y) 1062, to which PI3K- or ERK-activating proteins dock, or Y1015, to which PLC
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