Evidence map›Paper›PMID 29326130›Full record

ArticleCirculation. Arrhythmia and electrophysiology2018

Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias.

Ravi Vaidyanathan, Hanora Van Ert, Kazi T Haq, Stefano Morotti, Samuel Esch, Elise C McCune, Eleonora Grandi, Lee L Eckhardt

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Frontiers in physiology · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Caveolin-3 and Caveolae regulate ventricular repolarization.Journal of molecular and cellular cardiology · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy.American journal of physiology. Gastrointestinal and liver physiology · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ravi VaidyanathanFrom the Division of Cardiovascular Medicine and the Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin, Madison (R.V., H.V.E., S.E., E.C.M., L.L.E.); and Department of Pharmacology, University of California Davis (K.T.H., S.M., E.G.).
Hanora Van ErtFrom the Division of Cardiovascular Medicine and the Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin, Madison (R.V., H.V.E., S.E., E.C.M., L.L.E.); and Department of Pharmacology, University of California Davis (K.T.H., S.M., E.G.).
Kazi T HaqFrom the Division of Cardiovascular Medicine and the Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin, Madison (R.V., H.V.E., S.E., E.C.M., L.L.E.); and Department of Pharmacology, University of California Davis (K.T.H., S.M., E.G.).
Stefano MorottiFrom the Division of Cardiovascular Medicine and the Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin, Madison (R.V., H.V.E., S.E., E.C.M., L.L.E.); and Department of Pharmacology, University of California Davis (K.T.H., S.M., E.G.).
Samuel EschFrom the Division of Cardiovascular Medicine and the Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin, Madison (R.V., H.V.E., S.E., E.C.M., L.L.E.); and Department of Pharmacology, University of California Davis (K.T.H., S.M., E.G.).
Elise C McCuneFrom the Division of Cardiovascular Medicine and the Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin, Madison (R.V., H.V.E., S.E., E.C.M., L.L.E.); and Department of Pharmacology, University of California Davis (K.T.H., S.M., E.G.).
Eleonora GrandiFrom the Division of Cardiovascular Medicine and the Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin, Madison (R.V., H.V.E., S.E., E.C.M., L.L.E.); and Department of Pharmacology, University of California Davis (K.T.H., S.M., E.G.).
Lee L EckhardtFrom the Division of Cardiovascular Medicine and the Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin, Madison (R.V., H.V.E., S.E., E.C.M., L.L.E.); and Department of Pharmacology, University of California Davis (K.T.H., S.M., E.G.). lle@medicine.wisc.edu.
University of Wisconsin–Madison · US

Funding

Sex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0M
Arrhythmia Mechanisms from Inherited and Acquired Caveolin3 Dysregulation of IK1R01HL128598 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI ECKHARDT, LEE LOCHBAUM · 2015 to 2019
$1.9M
NHLBI NIH HHS R01 HL128598NHLBI NIH HHS R01 HL131517
6 · The paper itself

Abstract

backgroundIn human cardiac ventricle, METHODS AND

resultsSuper-resolution microscopy, co-immunoprecipitation, cellular electrophysiology, on-cell Western blotting, and simulation of Purkinje and ventricular myocyte mathematical models were used. Kir2.x isoforms have unique subcellular colocalization in human cardiomyocytes and coimmunoprecipitate with Cav3. F97C-Cav3 decreased peak inward Kir2.2 current density by 50% (-120 mV;

conclusionsKir2.x isoforms have a unique intracellular pattern of distribution in association with specific Cav3 domains and that critically depends on interaction with N-terminal Kir2.x Cav3-binding motifs. Long-QT syndrome-9-

Indexed as

MutationCaveolin 3Cells, CulturedDNADNA Mutational AnalysisHeart VentriclesHumansMembrane PotentialsMyocytes, CardiacPatch-Clamp TechniquesPolymerase Chain ReactionPotassium Channels, Inwardly RectifyingPurkinje CellsTachycardia, VentricularCaveolin 3DNAPotassium Channels, Inwardly Rectifyingblotting, Westernimmunoprecipitationmutationpotassium channelsPurkinje cells

Identifiers

PMID29326130
PMCPMC5771420
OpenAlexW2783737783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.