Evidence map›Paper›PMID 29326122›Full record

ArticleHaematologica2018

Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome.

Aniththa Thivakaran, Lacramioara Botezatu, Judith M Hönes, Judith Schütte, Lothar Vassen, Yahya S Al-Matary, Pradeep Patnana, Amos Zeller, Michael Heuser, Felicitas Thol and 11 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Germline risk of clonal haematopoiesis.Nature reviews. Genetics · 2021
    Review
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  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 2 countries.

Aniththa ThivakaranDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Lacramioara BotezatuDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Judith M HönesDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Judith SchütteDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Lothar VassenDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Yahya S Al-MataryDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Pradeep PatnanaDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Amos ZellerDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Michael HeuserDepartment of Haematology, Haemostaseology, Oncology, and Stem Cell Transplantation, Medical University of Hannover, Germany.
Felicitas TholDepartment of Haematology, Haemostaseology, Oncology, and Stem Cell Transplantation, Medical University of Hannover, Germany.
Razif GabdoullineDepartment of Haematology, Haemostaseology, Oncology, and Stem Cell Transplantation, Medical University of Hannover, Germany.
Nadine OlberdingDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Daria FrankDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Marina SusloDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Renata KösterDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Klaus LennartzInstitute for Cell Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Andre GörgensInstitute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Bernd GiebelInstitute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Bertram OpalkaDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Ulrich DührsenDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Cyrus KhandanpourDepartment of Haematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany cyrus.khandanpour@uk-essen.de.
University of Duisburg-Essen · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differentiation of hematopoietic stem cells is regulated by a concert of different transcription factors. Disturbed transcription factor function can be the basis of (pre)malignancies such as myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Growth factor independence 1b (Gfi1b) is a repressing transcription factor regulating quiescence of hematopoietic stem cells and differentiation of erythrocytes and platelets. Here, we show that low expression of

Indexed as

AnimalsEpigenomicsForkhead Box Protein O1Gene DeletionHeterozygoteHomozygoteHumansLeukemia, Myeloid, AcuteMiceMyelodysplastic Syndromesp38 Mitogen-Activated Protein KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktReactive Oxygen SpeciesRepressor ProteinsForkhead Box Protein O1Foxo1 protein, mouseGFI1B protein, humanp38 Mitogen-Activated Protein KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktReactive Oxygen SpeciesRepressor Proteins

Identifiers

PMID29326122
PMCPMC5865438
OpenAlexW2782597372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.