ArticleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2018
Genomics of Corynebacterium striatum, an emerging multidrug-resistant pathogen of immunocompromised patients.
Article in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 53 citations in OpenAlex.
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- Rising prevalence and drug resistance ofFrontiers in cellular and infection microbiology · 2024Review
- Deciphering the microbial landscape of lower respiratory tract infections: insights from metagenomics and machine learning.Frontiers in cellular and infection microbiology · 2024Article
- Review
- Pangenome analysis of Corynebacterium striatum: insights into a neglected multidrug-resistant pathogen.BMC microbiology · 2023Article
- Phylogenetic analyses of antimicrobial resistant Corynebacterium striatum strains isolated from a nosocomial outbreak in a tertiary hospital in China.Antonie van Leeuwenhoek · 2023Article
- Corynebacterium guaraldiae sp. nov.: a new species of Corynebacterium from human infections.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Prospective Genomic Surveillance Reveals Cryptic MRSA Outbreaks with Local to International Origins among NICU Patients.Journal of clinical microbiology · 2023Article
- Prescription of Rifampicin forPathogens (Basel, Switzerland) · 2023Article
- Novel configurations of type I-E CRISPR-Cas system in Corynebacterium striatum clinical isolates.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Multidrug-resistant toxigenicMicrobial genomics · 2023Article
- Genome-scale metabolic models consistently predictFrontiers in bioinformatics · 2023Article
- Clinical Efficiency of Metagenomic Next-Generation Sequencing in Sputum for Pathogen Detection of Patients with Pneumonia According to Disease Severity and Host Immune Status.Infection and drug resistance · 2023Article
- The pan-genome of the emerging multidrug-resistant pathogen Corynebacterium striatum.Functional & integrative genomics · 2022Article
- Current Methods for Recombination Detection in Bacteria.International journal of molecular sciences · 2022Review
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesCorynebacterium striatum is an emerging multidrug-resistant (MDR) pathogen of immunocompromised and chronically ill patients. The objective of these studies was to provide a detailed genomic analysis of disease-causing C. striatum and determine the genomic drivers of resistance and resistance-gene transmission.
methodsA multi-institutional and prospective pathogen genomics programme flagged seven MDR C. striatum infections occurring close in time, and specifically in immunocompromised patients with underlying respiratory diseases. Whole genome sequencing was used to identify clonal relationships among strains, genetic causes of antimicrobial resistance, and their mobilization capacity. Matrix-assisted linear desorption/ionization-time-of-flight analyses of sequenced isolates provided curated content to improve rapid clinical identification in subsequent cases.
resultsEpidemiological and genomic analyses identified a related cluster of three out of seven C. striatum among lung transplant patients who had common procedures and exposures at an outlying institution. Genomic analyses further elucidated drivers of the MDR phenotypes, including resistance genes mobilized by IS3504 and ISCg9a-like insertion sequences. Seven mobilizable resistance genes were localized to a common chromosomal region bounded by unpaired insertion sequences, suggesting that a single recombination event could spread resistance to aminoglycosides, macrolides, lincosamides and tetracyclines to naive strains.
conclusionIn-depth genomic studies of MDR C. striatum reveal its capacity for clonal spread within and across healthcare institutions and identify novel vectors that can mobilize multiple forms of drug resistance, further complicating efforts to treat infections in immunocompromised populations.
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