Evidence map›Paper›PMID 29325977›Full record

ArticleHeart rhythm2018

Role of apamin-sensitive small conductance calcium-activated potassium currents in long-term cardiac memory in rabbits.

Dechun Yin, Mu Chen, Na Yang, Adonis Z Wu, Dongzhu Xu, Wei-Chung Tsai, Yuan Yuan, Zhipeng Tian, Yi-Hsin Chan, Changyu Shen and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. The Inhibition of the Small-Conductance CaPharmaceuticals (Basel, Switzerland) · 2022
    Article
  2. Review
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 4 countries.

Dechun YinKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Mu ChenDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Na YangKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Gynecological and Obstetric Ultrasound, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Adonis Z WuKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Institute of Biomedical Engineering, National Chiao-Tung University, Hsin-Chu, Taiwan.
Dongzhu XuKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Wei-Chung TsaiDivision of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yuan YuanDepartment of Cardiothoracic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhipeng TianKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Cardiology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, China.
Yi-Hsin ChanKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Linkou, Taoyuan, Taiwan.
Changyu ShenRichard and Susan Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Zhenhui ChenKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Shien-Fong LinInstitute of Biomedical Engineering, National Chiao-Tung University, Hsin-Chu, Taiwan.
James N WeissDepartments of Medicine and Physiology, University of California, Los Angeles, California.
Peng-Sheng ChenKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Thomas H EverettKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: theveret@iu.edu.
Indiana University School of MedicineHarbin Medical University · CNNational Yang Ming Chiao Tung University · TWShanghai Jiao Tong University · CNBeth Israel Deaconess Medical Center · USCentral Hospital Affiliated to Shenyang Medical College · CNChang Gung University · TWKaohsiung Medical University · TWUniversity of California, Los Angeles · USUniversity of Tsukuba · JP

Funding

WAVE DYNAMICS IN NORMAL AND DISEASED RABBIT HEARTSP01HL078931 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, JAMES · 2005 to 2015
$20.7M
Thoracic Veins and Sustained Atrial FibrillationR01HL071140 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CHEN, PENG-SHENG · 2002 to 2014
$4.7M
SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular ArrhythmogenesisR01HL139829 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PENG-SHENG CHEN, ZHILIN QU · 2018 to 2026
$4.5M
Skin Sympathetic Nerve Activity and Cardiac ArrhythmiasR42DA043391 · NIDA · ARRHYTHMOTECH, LLC · PI EVERETT, THOMAS H · 2016 to 2017
$1.5M
Subcutaneous nerve stimulation for arrhythmia control.U18TR002208 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI CHEN, PENG-SHENG · 2017 to 2018
$1.4M
Neuromodulation for Atrial Fibrillation ControlR56HL071140 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI CHEN, PENG-SHENG · 2016 to 2016
$461k
Sympathetic Nerve Activity Recorded From the Skin and Cardiac ArrhythmiasR41HL124741 · NHLBI · ARRHYTHMOTECH, LLC · PI EVERETT, THOMAS H · 2014 to 2014
$213k
NCATS NIH HHS U18 TR002208NHLBI NIH HHS P01 HL078931NHLBI NIH HHS R01 HL071140NHLBI NIH HHS R01 HL139829NHLBI NIH HHS R41 HL124741NHLBI NIH HHS R56 HL071140NIDA NIH HHS R42 DA043391
6 · The paper itself

Abstract

backgroundApamin-sensitive small conductance calcium-activated K current (I

objectiveThe purpose of this study was to determine the role of I

methodsCM was created with 3-5 weeks of ventricular pacing and defined by a flat or inverted T wave off pacing. Epicardial optical mapping was performed in both paced and normal ventricles. Action potential duration (APD

resultsThere were no significant differences in either echocardiographic parameters or fibrosis levels between groups. Apamin induced more APD

conclusionChronic ventricular pacing increases Ca

Indexed as

Action PotentialsAnimalsApaminBlotting, WesternDisease Models, AnimalEchocardiographyFemaleHeart VentriclesImmunohistochemistryPatch-Clamp TechniquesPolymerase Chain ReactionRabbitsRNASmall-Conductance Calcium-Activated Potassium ChannelsVentricular FibrillationApaminKCNN2 protein, humanKCNN3 protein, humanRNASmall-Conductance Calcium-Activated Potassium ChannelsCardiac memoryElectrophysiologyIon channelVentricular fibrillation

Identifiers

PMID29325977
PMCPMC5930041
OpenAlexW2783928682

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.