Evidence map›Paper›PMID 29325535›Full record

SynthesisBMC cancer2018

Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis.

Eileen Shaw, Megan S Farris, Chelsea R Stone, Jeroen W G Derksen, Rhys Johnson, Robert J Hilsden, Christine M Friedenreich, Darren R Brenner

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Physical Activity in Cancer Prevention and Survival: A Systematic Review.Medicine and science in sports and exercise · 2019
    Pooled it
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Epidemiology of colorectal cancer: A review with special emphasis on India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Review
  11. Pharmacological role ofWorld journal of gastrointestinal oncology · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Eileen ShawDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 2nd Street S.W., Calgary, AB, T2S 3C3, Canada.
Megan S FarrisDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 2nd Street S.W., Calgary, AB, T2S 3C3, Canada.
Chelsea R StoneDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 2nd Street S.W., Calgary, AB, T2S 3C3, Canada.
Jeroen W G DerksenDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 2nd Street S.W., Calgary, AB, T2S 3C3, Canada.
Rhys JohnsonDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 2nd Street S.W., Calgary, AB, T2S 3C3, Canada.
Robert J HilsdenDepartment of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Christine M FriedenreichDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 2nd Street S.W., Calgary, AB, T2S 3C3, Canada.
Darren R BrennerDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 2nd Street S.W., Calgary, AB, T2S 3C3, Canada. darren.brenner@ucalgary.ca.
Alberta Health Services · CAUniversity of Calgary · CA

Funding

Canadian Cancer Society Research Institute 703917
6 · The paper itself

Abstract

backgroundPhysical activity is consistently associated with a reduced risk of colorectal cancer in epidemiologic studies. This association among higher risk subgroups, such as those with a first-degree family history of colorectal cancer or high body mass index remains unclear.

methodsWe searched MEDLINE for studies examining physical activity and colorectal cancer risk among higher risk subgroups through July 11, 2017. Fifteen and three studies were eligible for inclusion for body mass index and first-degree family history of colorectal cancer subgroups, respectively. Estimates of the highest to lowest comparison of physical activity for each subgroup of risk were pooled using random-effects models.

resultsThe pooled associations of physical activity and colorectal cancer risk for those without and with a first-degree family history of colorectal cancer were 0.56 (95% confidence interval (CI) = 0.39-0.80) and 0.72 (95% CI = 0.39-1.32), respectively (p

conclusionsOverall, a stronger relative risk of physical activity on colorectal cancer risk was observed in the higher body mass index group, although the difference was not statistically significant, suggesting an added benefit of physical activity as a cancer prevention strategy in population groups with strong risk factors for colorectal cancer. Additional research among these subgroups is warranted.

Indexed as

ExerciseMedical History TakingBody Mass IndexColorectal NeoplasmsFemaleHumansMaleRisk FactorsBody mass indexColorectal neoplasmsExerciseFamily historyRisk

Identifiers

PMID29325535
PMCPMC5763991
OpenAlexW2783285062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.