ArticleThe American journal of psychiatry2018
Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood.
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Article in The American journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 5 of them syntheses that pooled it.
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68citing papers in PubMed, 5 pooled it
23.9field-weighted citation impact, top 1% of its field
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Who cites it
68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review.Neuroscience and biobehavioral reviews · 2023Pooled it
- A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.Translational psychiatry · 2021Pooled it
- Adverse Childhood Events and Health Biomarkers: A Systematic Review.Frontiers in public health · 2021Pooled it
- Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR.Nature communications · 2020Pooled it
- Epigenetics in eating disorders: a systematic review.Molecular psychiatry · 2019Pooled it
- Prenatal social support in low-risk pregnancy shapes placental epigenome.BMC medicine · 2023Trial
- Review
- Bullying as an Adverse Childhood Experience?-State of the Art.Children (Basel, Switzerland) · 2026Review
- Article
- Interactive effects of genotype with prenatal stress on DNA methylation at birth.Molecular psychiatry · 2025Article
- Review
- Peer victimization in adolescence alters gene expression and cytokine profiles during transition to adulthood.Brain, behavior, & immunity - health · 2025Article
- Epigenetics in persons living with HIV: trauma, coping, andEpigenomics · 2025Article
- Epigenetic Control in Schizophrenia.Sub-cellular biochemistry · 2025Review
- Article
- Impacts of Polyenvironmental Factors on DNA Methylation in Patients With Psychosis.Schizophrenia bulletin open · 2025Article
- DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study.American journal of epidemiology · 2024Article
- Epigenetic Regulation in Schizophrenia: Focus on Methylation and Histone Modifications in Human Studies.Genes · 2024Review
- Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery.Biomolecules · 2024Review
- Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 1 institution in 1 country.
Sarah J MarziFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Karen SugdenFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Louise ArseneaultFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Daniel W BelskyFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Joe BurrageFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
David L CorcoranFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Andrea DaneseFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Helen L FisherFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Eilis HannonFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Terrie E MoffittFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Candice L OdgersFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Carmine ParianteFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Richie PoultonFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Benjamin S WilliamsFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Chloe C Y WongFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Jonathan MillFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
Avshalom CaspiFrom the Social, Genetic, and Developmental Psychiatry Research Centre, the Department of Child and Adolescent Psychiatry, and the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience, Social Science Research Institute, and the Center for Genomic and Computational Biology, Duke University, Durham, N.C.; the Department of Psychiatry and Behavioral Sciences, the Department of Population Health Sciences, and the Department of Medicine, Duke University School of Medicine, Durham, N.C.; the Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand; and the Complex Disease Epigenetics Group, University of Exeter Medical School, Exeter, U.K.
South London and Maudsley NHS Foundation Trust · GB
Funding
STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI SCOTT M. LYNCH · 2009 to 2026
$12.2MIs mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5MScience CoreP2CHD065563 · NICHD · DUKE UNIVERSITY · PI James Moody · 2015 to 2026
$5.7MNeuropsychological and genomic signatures of violence exposure in childhoodR01HD077482 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2013 to 2018
$2.8MData commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598kMedical Research Council G1002190Medical Research Council G108/603Medical Research Council MR/N029488/1Medical Research Council MR/P005918/1NIA NIH HHS R01 AG032282NICHD NIH HHS P2C HD065563NICHD NIH HHS R01 HD077482NIH HHS S10 OD018164Wellcome Trust
Abstract
objectiveDNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become "embedded" in the genome and alter transcriptional processes to compromise health. The authors sought to investigate whether early-life victimization stress is associated with genome-wide DNA methylation.
methodThe authors tested the hypothesis that victimization is associated with DNA methylation in the Environmental Risk (E-Risk) Longitudinal Study, a nationally representative 1994-1995 birth cohort of 2,232 twins born in England and Wales and assessed at ages 5, 7, 10, 12, and 18 years. Multiple forms of victimization were ascertained in childhood and adolescence (including physical, sexual, and emotional abuse; neglect; exposure to intimate-partner violence; bullying; cyber-victimization; and crime).
resultsEpigenome-wide analyses of polyvictimization across childhood and adolescence revealed few significant associations with DNA methylation in peripheral blood at age 18, but these analyses were confounded by tobacco smoking and/or did not survive co-twin control tests. Secondary analyses of specific forms of victimization revealed sparse associations with DNA methylation that did not replicate across different operationalizations of the same putative victimization experience. Hypothesis-driven analyses of six candidate genes in the stress response (NR3C1, FKBP5, BDNF, AVP, CRHR1, SLC6A4) did not reveal predicted associations with DNA methylation in probes annotated to these genes.
conclusionsFindings from this epidemiological analysis of the epigenetic effects of early-life stress do not support the hypothesis of robust changes in DNA methylation in victimized young people. We need to come to terms with the possibility that epigenetic epidemiology is not yet well matched to experimental, nonhuman models in uncovering the biological embedding of stress.
Indexed as
Crime VictimsDNA MethylationEpigenesis, GeneticAdolescentAge FactorsChildChild AbuseChild, PreschoolGenesHumansLongitudinal StudiesStress, PsychologicalDNA MethylationEpigeneticsMaltreatmentStress
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