Evidence map›Paper›PMID 29325163›Full record

SynthesisThe Journal of clinical endocrinology and metabolism2018

Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations.

Jaeyoung Hong, Kathryn E Hatchell, Jonathan P Bradfield, Andrew Bjonnes, Alessandra Chesi, Chao-Qiang Lai, Carl D Langefeld, Lingyi Lu, Yingchang Lu, Pamela L Lutsey and 50 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of clinical endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Early High-Dose Vitamin DThe New England journal of medicine · 2019
    Trial
  7. Article
  8. Article
  9. Article
  10. The plasma free fraction of 25-hydroxyvitamin DThe Journal of steroid biochemistry and molecular biology · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

60 authors at 20 institutions in 1 country.

Jaeyoung HongDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Kathryn E HatchellDepartment of Population Health Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Jonathan P BradfieldCenter for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Andrew BjonnesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Alessandra ChesiThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Chao-Qiang LaiUSDA-ARS Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.
Carl D LangefeldWake Forest School of Medicine, Winston-Salem, North Carolina.
Lingyi LuWake Forest School of Medicine, Winston-Salem, North Carolina.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Pamela L LutseyDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.
Solomon K MusaniDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Mike A NallsData Tecnica International, Glen Echo, Maryland.
Cassianne Robinson-CohenKidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.
Jeffery D RoizenCenter for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Richa SaxenaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Katherine L TuckerDepartment of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, Massachusetts.
Julie T ZieglerWake Forest School of Medicine, Winston-Salem, North Carolina.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Eric BoerwinkleUniversity of Texas Health Science Center at Houston, Houston, Texas.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Donald W BowdenWake Forest School of Medicine, Winston-Salem, North Carolina.
Vicente GilsanzDepartment of Radiology, Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.
Denise K HoustonDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Heidi J KalkwarfDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Andrea KellyThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Joan M LappeCreighton University, Omaha, Nebraska.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Erin D MichosCiccarone Center for the Prevention of Heart Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Sharon E OberfieldDivision of Pediatric Endocrinology, Diabetes and Metabolism, Columbia University Medical Center, New York, New York.
Nicholette D PalmerWake Forest School of Medicine, Winston-Salem, North Carolina.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Department of Pediatrics and Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California.
Bishwa SapkotaDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
John A ShepherdUniversity of California San Francisco School of Medicine, San Francisco, California.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Saonli BasuDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota.
Ian H de BoerKidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.
Jasmin DiversWake Forest School of Medicine, Winston-Salem, North Carolina.
Barry I FreedmanWake Forest School of Medicine, Winston-Salem, North Carolina.
Struan F A GrantCenter for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Hakon HakanarsonCenter for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland.
Bryan R KestenbaumKidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.
Stephen B KritchevskyDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado.
Arnita F NorwoodDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Jose M OrdovasNutrition and Genomics, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.
James S PankowDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Dharambir K SangheraDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Lynne E WagenknechtWake Forest School of Medicine, Winston-Salem, North Carolina.
Babette S ZemelThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
James MeigsDivision of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Jose C FlorezCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Thomas WangVanderbilt University, Nashville, Tennessee.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Corinne D EngelmanDepartment of Population Health Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Liana K BillingsNorthShore University HealthSystem, Evanston, Illinois.
Wake Forest University · USChildren's Hospital of Philadelphia · USUniversity of Washington · USUniversity of Minnesota · USBoston University · USHarvard University · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USMassachusetts General Hospital · USNational Institute on Aging · USTufts University · USUniversity of Mississippi Medical Center · USUniversity of Oklahoma Health Sciences Center · USUniversity of Pennsylvania · USUniversity of Wisconsin–Madison · USChild Health and Development Institute · USCincinnati Children's Hospital Medical Center · USColumbia University Irving Medical Center · USCreighton University · USFramingham Heart Study · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Research Training for Computation and Informatics in Biology and MedicineT15LM007359 · NLM · UNIVERSITY OF WISCONSIN-MADISON · PI Mark W. Craven, Colin Noel Dewey · 2002 to 2026
$22.6M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCRR NIH HHS M01 RR007122NCRR NIH HHS UL1 RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG007417NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS P50 HL105185NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL060919NHLBI NIH HHS R01 HL060944NHLBI NIH HHS R01 HL061019NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL096875NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL103706NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R56 HL124004NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS P01 AG023394NIA NIH HHS P30 AG017266NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG028050NIA NIH HHS R01 AG029364NIA NIH HHS R01 AG032098NICHD NIH HHS K08 HD087964NICHD NIH HHS P2C HD047873NICHD NIH HHS R01 HD056465NICHD NIH HHS R01 HD058886NICHD NIH HHS R01 HD076321NIDDK NIH HHS K01 DK109019NIDDK NIH HHS K12 DK094723NIDDK NIH HHS K24 DK080140NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK071891NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK082766NIDDK NIH HHS R01 DK085175NIDDK NIH HHS T32 DK007028NIDDK NIH HHS U01 DK078616NIEHS NIH HHS P30 ES013508NIGMS NIH HHS U54 GM115428NIH HHS S10 OD018522NINR NIH HHS R01 NR012459NLM NIH HHS T15 LM007359
6 · The paper itself

Abstract

Context: Vitamin D inadequacy is common in the adult population of the United States. Although the genetic determinants underlying vitamin D inadequacy have been studied in people of European ancestry, less is known about populations with Hispanic or African ancestry. Objective: The Trans-Ethnic Evaluation of Vitamin D (TRANSCEN-D) genomewide association study (GWAS) consortium was assembled to replicate genetic associations with 25-hydroxyvitamin D [25(OH)D] concentrations from the Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits (SUNLIGHT) meta-analyses of European ancestry and to identify genetic variants related to vitamin D concentrations in African and Hispanic ancestries. Design: Ancestry-specific (Hispanic and African) and transethnic (Hispanic, African, and European) meta-analyses were performed with Meta-Analysis Helper software (METAL). Patients or Other Participants: In total, 8541 African American and 3485 Hispanic American (from North America) participants from 12 cohorts and 16,124 European participants from SUNLIGHT were included in the study. Main Outcome Measures: Blood concentrations of 25(OH)D were measured for all participants. Results: Ancestry-specific analyses in African and Hispanic Americans replicated single nucleotide polymorphisms (SNPs) in GC (2 and 4 SNPs, respectively). An SNP (rs79666294) near the KIF4B gene was identified in the African American cohort. Transethnic evaluation replicated GC and DHCR7 region SNPs. Additionally, the transethnic analyses revealed SNPs rs719700 and rs1410656 near the ANO6/ARID2 and HTR2A genes, respectively. Conclusions: Ancestry-specific and transethnic GWASs of 25(OH)D confirmed findings in GC and DHCR7 for African and Hispanic American samples and revealed findings near KIF4B, ANO6/ARID2, and HTR2A. The biological mechanisms that link these regions with 25(OH)D metabolism warrant further investigation.

Indexed as

AdolescentAdultAgedBlack or African AmericanBody Mass IndexChildFemaleGene FrequencyGenetic LociGenome-Wide Association StudyHispanic or LatinoHumansMaleMiddle AgedPolymorphism, Single NucleotideUnited States25-hydroxyvitamin DVitamin D

Identifiers

PMID29325163
PMCPMC6276579
OpenAlexW2782931868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.