ArticleSocial cognitive and affective neuroscience2018
Anxiety-dependent modulation of motor responses to pain expectancy.
Article in Social cognitive and affective neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Spatial proximity to others induces plastic changes in the neural representation of the peripersonal space.iScience · 2023Article
- Can static Rorschach stimuli perceived as in motion affect corticospinal excitability?PloS one · 2023Article
- Modulation of vestibular input by short-term head-down bed rest affects somatosensory perception: implications for space missions.Frontiers in neural circuits · 2023Article
- Pavlovian threat learning shapes the kinematics of action.Frontiers in psychology · 2022Article
- Resistance to local anesthesia in people with the Ehlers-Danlos Syndromes presenting for dental surgery.Journal of dental anesthesia and pain medicine · 2019Article
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Authors and funding
7 authors.
Funding
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Abstract
The relationship between pain expectancy and motor system plays a crucial role in the human defensive system. Here, we took advantage of the inhibitory modulation of the motor pathway to the muscle of the hand receiving painful stimuli, by recording motor-evoked potentials (MEPs) to Transcranial Magnetic Stimulation (TMS). We employed a classical conditioning paradigm in which neutral (visual and auditory) stimuli were conditioned by pairing either painful or not-painful stimuli (electric shocks) in separated groups. Only the Pain Group showed clear motor responses: i.e. a significant decrease in MEPs amplitude, with respect to the neutral condition, not only in conditioning stimuli, when actual shocks were paired with neutral stimuli, but also in conditioned stimuli, when shocks were only expected. Significant differences between the two groups suggest that the MEPs decrease is specific for pain expectancy and does not pertain to anticipation in general. Furthermore, in the Pain Group, a significant negative correlation between physiological responses to conditioned stimuli and the participants' anxiety traits was found: the lower the MEPs amplitude, the higher the participants' anxiety scores. The present findings suggest that, in order for defensive motor responses to occur, actual pain is not necessary; rather, anxiety-dependent pain expectancy can be sufficient.
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Registered trials
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