Evidence map›Paper›PMID 29324775›Full record

ArticlePloS one2018

The optimal threshold of serum ceruloplasmin in the diagnosis of Wilson's disease: A large hospital-based study.

Rong Xu, Yong-Fang Jiang, Yong-Hong Zhang, Xu Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Biomarkers for diagnosis of Wilson's disease.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Article
  4. Insights into the coexistence of WilsonLiver research (Beijing, China) · 2025
    Article
  5. Article
  6. Review
  7. Monitoring of Copper in Wilson Disease.Diagnostics (Basel, Switzerland) · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rong XuInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Yong-Fang JiangDepartment of Infectious Diseases/ Liver Disease Research Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Yong-Hong ZhangDepartment of Infectious Diseases/ Liver Disease Research Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Xu YangDepartment of Infectious Diseases/ Liver Disease Research Center, The Second Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0001-6660-6417
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsA ceruloplasmin (CP) concentration <200 mg/L is conventionally considered as one of the major diagnostic criteria for Wilson's disease (WD). However, the diagnostic accuracy of this threshold has never been investigated in a sufficiently large group of patients. This study aims to present the results of serum CP measurements in various patients and to identify the optimal cutoff value of CP for the diagnosis of WD. MATERIALS AND

methodsWe identified patients whose CP levels were evaluated from January 1, 2016 to December 31, 2016 using a laboratory information database. Data related to CP measurement were retrieved. We carefully reviewed patients' electronic medical records to correct errors and to obtain other necessary data. Data related to WD were retrieved from a special document containing medical records of patients with WD, which were created, modified, and maintained by authors.

resultsCP level was determined in 4048 patients (WD, 297; non-WD, 3751). The mean serum CP level in patients with WD was 50.6±44.2 mg/L, which was significantly lower than that in non-WD patients (293.2±117.3 mg/L, p<0.001). Only 1.0% of patients with WD had CP ≥200 mg/L. The sensitivity and specificity of CP for the diagnosis of WD were 99.0 and 80.9%, respectively, for the conventional cutoff value <200 mg/L and 95.6 and 95.5%, respectively, for the cutoff value <150 mg/L; the latter provided a higher diagnostic accuracy for WD. 53.0% of patients with liver failure, 37.7% of patients with nephrotic syndrome, and 23.0% of patients age 1 to 6 months had serum CP <200 mg/L. Patients who were pregnant and those with malignant tumors, and infectious and inflammatory diseases had significantly higher mean serum CP levels.

conclusionThe optimal cutoff value of CP for the diagnosis of WD in China is 150 mg/L, with a sensitivity of 95.6% and specificity of 95.5%, thereby providing the highest diagnostic accuracy for WD.

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkersCeruloplasminChildChild, PreschoolChinaElectronic Health RecordsFemaleFollow-Up StudiesHepatolenticular DegenerationHospitalizationHumansInfantBiomarkersCeruloplasmin

Identifiers

PMID29324775
PMCPMC5764328
OpenAlexW2783477151

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.