ArticlePLoS computational biology2018
Identifying human diamine sensors for death related putrescine and cadaverine molecules.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Microbial volatile organic compounds and olfactory receptors in wound malodor.Frontiers in cellular and infection microbiology · 2026Pooled it
- Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.Biomolecules · 2022Pooled it
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
- Structural insights on the ligand selectivity of the mouse trace amine-associated receptor TAAR7e.iScience · 2026Article
- Differences in metabolic profiles of lupin-based beverages produced with various fermentation techniques.NPJ science of food · 2026Article
- Adaptive Machine Learning for Electronic Nose-Based Forensic VOC Classification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- TAAR8 in the Brain: Implications for Dopaminergic Function, Neurogenesis, and Behavior.Biomedicines · 2025Article
- TAAR8 Mediates Increased Migrasome Formation by Cadaverine in RPE Cells.Current issues in molecular biology · 2024Article
- Functional Polymeric Membranes with Antioxidant Properties for the Colorimetric Detection of Amines.Sensors (Basel, Switzerland) · 2023Article
- Amine-recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Selection signature analysis revealsArchives animal breeding · 2023Article
- Article
- Evolution of Brain-Expressed Biogenic Amine Receptors into Olfactory Trace Amine-Associated Receptors.Molecular biology and evolution · 2022Article
- Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.International journal of molecular sciences · 2021Article
- Accumulation and Transformation of Biogenic Amines and Gamma-Aminobutyric Acid (GABA) in Chickpea Sourdough.Foods (Basel, Switzerland) · 2021Article
- Polyamines: Functions, Metabolism, and Role in Human Disease Management.Medical sciences (Basel, Switzerland) · 2021Review
- Olfactory signaling via trace amine-associated receptors.Cell and tissue research · 2021Review
- Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease.Cell host & microbe · 2020Article
- TAAR Agonists.Cellular and molecular neurobiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pungent chemical compounds originating from decaying tissue are strong drivers of animal behavior. Two of the best-characterized death smell components are putrescine (PUT) and cadaverine (CAD), foul-smelling molecules produced by decarboxylation of amino acids during decomposition. These volatile polyamines act as 'necromones', triggering avoidance or attractive responses, which are fundamental for the survival of a wide range of species. The few studies that have attempted to identify the cognate receptors for these molecules have suggested the involvement of the seven-helix trace amine-associated receptors (TAARs), localized in the olfactory epithelium. However, very little is known about the precise chemosensory receptors that sense these compounds in the majority of organisms and the molecular basis of their interactions. In this work, we have used computational strategies to characterize the binding between PUT and CAD with the TAAR6 and TAAR8 human receptors. Sequence analysis, homology modeling, docking and molecular dynamics studies suggest a tandem of negatively charged aspartates in the binding pocket of these receptors which are likely to be involved in the recognition of these small biogenic diamines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.