ArticleThe Journal of clinical investigation1985
Immunoglobulin G is a platelet alpha granule-secreted protein.
Article in The Journal of clinical investigation, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 79 citations in OpenAlex.
- Megakaryocytes Internalize and Are Activated by Immune Complexes.Circulation research · 2026Article
- IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis.The Journal of clinical investigation · 2022Article
- Enrichment of Complement, Immunoglobulins, and Autoantibody Targets in the Proteome of Platelets from Patients with Systemic Lupus Erythematosus.Thrombosis and haemostasis · 2022Article
- A comparative profile of total protein and six angiogenically-active growth factors in three platelet products.GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2022Article
- Immunoglobulin G in Platelet-Derived Wound Healing Factors.BioMed research international · 2021Article
- Platelets mediate serological memory to neutralize viruses in vitro and in vivo.Blood advances · 2020Article
- Fresh Evidence for Platelets as Neuronal and Innate Immune Cells: Their Role in the Activation, Differentiation, and Deactivation of Th1, Th17, and Tregs during Tissue Inflammation.Frontiers in immunology · 2018Review
- Assessment of Equine Autoimmune Thrombocytopenia (EAT) by flow cytometry.BMC blood disorders · 2001Article
- Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules.The Journal of clinical investigation · 1993Article
- Immunohistochemical and functional studies of glycoprotein 60 (gp60) in platelets.Rheumatology international · 1992Article
- Decreased content and surface expression of alpha-granule membrane protein GMP-140 in one of two types of platelet alpha delta storage pool deficiency.The Journal of clinical investigation · 1991Article
- In vivo defibrination results in markedly decreased amounts of fibrinogen in rat megakaryocytes and platelets.The American journal of pathology · 1990Article
- Platelet alpha-granule fibrinogen, albumin, and immunoglobulin G are not synthesized by rat and mouse megakaryocytes.The Journal of clinical investigation · 1990Article
- Naturally occurring human IgG antibodies to intracellular and cytoskeletal components of human platelets.Clinical and experimental immunology · 1990Article
- Uptake of plasma fibrinogen into the alpha granules of human megakaryocytes and platelets.The Journal of clinical investigation · 1989Article
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- Incorporation of intravenously injected albumin, immunoglobulin G, and fibrinogen in guinea pig megakaryocyte granules.The Journal of clinical investigation · 1989Article
- Article
- Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction.The Journal of clinical investigation · 1988Article
- Gray platelet syndrome. Demonstration of alpha granule membranes that can fuse with the cell surface.The Journal of clinical investigation · 1987Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
It has been known for 27 yr that blood platelets contain IgG, yet its subcellular location and significance have never been clearly determined. In these studies, the location of IgG within human platelets was investigated by immunocytochemical techniques and by the response of platelet IgG to agents that cause platelet secretion. Using frozen thin-sections of platelets and an immunogold probe, IgG was located within the alpha-granules. Thrombin stimulation caused parallel secretion of platelet IgG and two known alpha-granule proteins, platelet factor 4 and beta-thromboglobulin, beginning at 0.02 U/ml and reaching 100% at 0.5 U/ml. Thrombin-induced secretion of all three proteins was inhibited by prostaglandin E1 and dibutyryl-cyclic AMP. Calcium ionophore A23187 also caused parallel secretion of all three proteins, whereas ADP caused virtually no secretion of any of the three. From these data and a review of the literature, we hypothesize that plasma IgG is taken up by megakaryocytes and delivered to the alpha-granules, where it is stored for later secretion by mature platelets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.