ArticlePLoS neglected tropical diseases2018
Population structure analysis of the neglected parasite Thelazia callipaeda revealed high genetic diversity in Eastern Asia isolates.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Current understanding ofInternational journal for parasitology. Parasites and wildlife · 2026Review
- From Asia to Europe: epidemiology, genetic diversity, and One Health implications of Thelazia callipaeda.Parasite (Paris, France) · 2026Review
- Eye to eye withCurrent research in parasitology & vector-borne diseases · 2026Article
- Wild Japanese Marten,Ecology and evolution · 2025Article
- Thelaziosis in central Italy: Molecular detection of a variant haplotype in a human case and epidemiological aspects.Current research in parasitology & vector-borne diseases · 2025Article
- Human ocular thelaziasis with genetic analysis in Niigata Prefecture, Japan: A case report on an emerging zoonosis.American journal of ophthalmology case reports · 2024Article
- First report of Thelazia callipaeda Railliet & Henry, 1910 in a zoo lion (Panthera leo) (Linnaeus, 1758) from Romania.Veterinary research communications · 2023Article
- Occurrence of Thelazia callipaeda and its vector Phortica variegata in Austria and South Tyrol, Italy, and a global comparison by phylogenetic network analysis.Parasites & vectors · 2023Article
- Molecular characterization of oriental eyeworm (Thelazia callipaeda) detected from raccoon (Procyon lotor) and Japanese raccoon dog (Nyctereutes viverrinus) in Kanto region, Japan.Parasites & vectors · 2023Article
- Laboratory Culture and Life Cycle ofPathogens (Basel, Switzerland) · 2022Article
- Genetic and geographical delineation of zoonotic vector-borne helminths of canids.Scientific reports · 2022Article
- Hookworm infection in central China: morphological and molecular diagnosis.Parasites & vectors · 2021Review
- A human corneal ulcer caused by Thelazia callipaeda in Southwest China: case report.Parasitology research · 2020Article
- First report of canine ocular thelaziosis in the Republic of Moldova.Parasites & vectors · 2019Article
- Genotyping and Phylogenetic Position ofFrontiers in genetics · 2019Article
- Predicting the distribution of Phortica variegata and potential for Thelazia callipaeda transmission in Europe and the United Kingdom.Parasites & vectors · 2018Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThelazia callipaeda is the causative agent of thelaziasis in canids, felids and humans. However, the population genetic structure regarding this parasite remains unclear. METHODOLOGY/PRINCIPAL
findingsIn this study, we first explored the genetic variation of 32 T. callipaeda clinical isolates using the following multi-molecular markers: cox1, cytb, 12S rDNA, ITS1 and 18S rDNA. The isolates were collected from 13 patients from 11 geographical locations in China. Next, the population structure of T. callipaeda from Europe and other Asian countries was analyzed using the cox1 sequences collected during this study and from the GenBank database. In general, the Chinese clinical isolates of T. callipaeda expressed high genetic diversity. Based on the cox1 gene, a total of 21 haplotypes were identified. One only circulated in European countries (Hap1), while the other 20 haplotypes were dispersed in Korea, Japan and China. There were five nucleotide positions in the cox1 sequences that were confirmed as invariable among individuals from Europe and Asia, but the sequences were distinct between these two regions. Population differences between Europe and Asian countries were greater than those among China, Korea and Japan. The T. callipaeda populations from Europe and Asia should be divided into two separate sub-populations. These two groups started to diverge during the middle Pleistocene. Neutrality tests, mismatch distribution and Bayesian skyline plot (BSP) analysis all rejected possible population expansion of T. callipaeda.
conclusionsThe Asian population of T. callipaeda has a high level of genetic diversity, but further studies should be performed to explore the biology, ecology and epidemiology of T. callipaeda.
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