Evidence map›Paper›PMID 29324679›Full record

ArticleInternational journal of molecular sciences2018

Antibacterial Evaluation and Virtual Screening of New Thiazolyl-Triazole Schiff Bases as Potential DNA-Gyrase Inhibitors.

Cristina Nastasă, Dan C Vodnar, Ioana Ionuţ, Anca Stana, Daniela Benedec, Radu Tamaian, Ovidiu Oniga, Brînduşa Tiperciuc

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. ACS omega · 2022
    Article
  12. 1,2,4-Triazoles as Important Antibacterial Agents.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. ACS medicinal chemistry letters · 2019
    Article
  18. A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects andOxidative medicine and cellular longevity · 2019
    Article
  19. Cu(II) Complexes of 4-[(1Molecules (Basel, Switzerland) · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Cristina NastasăDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, RO-400012 Cluj-Napoca, Romania. cmoldovan@umfcluj.ro.
Dan C VodnarDepartment of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 3-5 Mănăştur Street, RO-400372 Cluj-Napoca, Romania. dan.vodnar@usamvcluj.ro.
Ioana IonuţDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, RO-400012 Cluj-Napoca, Romania. ionut.ioana@umfcluj.ro.
Anca StanaDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, RO-400012 Cluj-Napoca, Romania. teodora_anca@yahoo.com.
Daniela BenedecDepartment of Pharmacognosy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj-Napoca, Romania. dani_67ro@yahoo.com.
Radu TamaianNational Institute for Research and Development for Cryogenic and Isotopic Technologies, 4th Uzinei Street, RO-240050 Râmnicu Vâlcea, Romania. radu.tamaian@icsi.ro.ORCID 0000-0001-6380-1460
Ovidiu OnigaDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, RO-400012 Cluj-Napoca, Romania. onigao65@yahoo.com.
Brînduşa TiperciucDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, RO-400012 Cluj-Napoca, Romania. brandu32@yahoo.com.ORCID 0000-0002-1333-5649
Iuliu Hațieganu University of Medicine and Pharmacy · RONational Institute for Research and Development of Isotopic and Molecular Technologies · ROUniversity of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global spread of bacterial resistance to drugs used in therapy requires new potent and safe antimicrobial agents. DNA gyrases represent important targets in drug discovery. Schiff bases, thiazole, and triazole derivatives are considered key scaffolds in medicinal chemistry. Fifteen thiazolyl-triazole Schiff bases were evaluated for their antibacterial activity, measuring the growth inhibition zone diameter, the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC), against Gram-positive (

Indexed as

Molecular Docking SimulationAnti-Bacterial AgentsBacterial ProteinsBinding SitesDNA GyraseProtein BindingQuantitative Structure-Activity RelationshipSchiff BasesThiazolesTopoisomerase II InhibitorsTriazolesAnti-Bacterial AgentsBacterial ProteinsDNA GyraseSchiff BasesThiazolesTopoisomerase II InhibitorsTriazolesADMETantibacterial activityDNA-gyrasemolecular dockingSchiff basethiazoletriazole

Identifiers

PMID29324679
PMCPMC5796171
OpenAlexW2782578886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.