ArticlePhysics in medicine and biology2018
Hybrid dose calculation: a dose calculation algorithm for microbeam radiation therapy.
Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Microbeam radiotherapy - clinical and dosimetric investigation of a first clinical application.Radiation oncology (London, England) · 2026Article
- Recent advances in film dosimetry for quality assurance in microbeam radiation therapy.Scientific reports · 2025Article
- The Influence of Ionizing Radiation on Quantification for In Situ and Operando Liquid-Phase Electron Microscopy.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Article
- Treatment planning with high-resolution 3D dose maps in preclinical and translational synchrotron microbeam radiation therapy.Physics and imaging in radiation oncology · 2024Article
- Article
- Article
- A high-resolution dose calculation engine for X-ray microbeams radiation therapy.Medical physics · 2022Article
- Article
- Unexpected Benefits of Multiport Synchrotron Microbeam Radiation Therapy for Brain Tumors.Cancers · 2021Article
- Clinical microbeam radiation therapy with a compact source: specifications of the line-focus X-ray tube.Physics and imaging in radiation oncology · 2020Article
- Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron.Scientific reports · 2019Article
- Locomotion and eating behavior changes in Yucatan minipigs after unilateral radio-induced ablation of the caudate nucleus.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Microbeam radiation therapy (MRT) is still a preclinical approach in radiation oncology that uses planar micrometre wide beamlets with extremely high peak doses, separated by a few hundred micrometre wide low dose regions. Abundant preclinical evidence demonstrates that MRT spares normal tissue more effectively than conventional radiation therapy, at equivalent tumour control. In order to launch first clinical trials, accurate and efficient dose calculation methods are an inevitable prerequisite. In this work a hybrid dose calculation approach is presented that is based on a combination of Monte Carlo and kernel based dose calculation. In various examples the performance of the algorithm is compared to purely Monte Carlo and purely kernel based dose calculations. The accuracy of the developed algorithm is comparable to conventional pure Monte Carlo calculations. In particular for inhomogeneous materials the hybrid dose calculation algorithm out-performs purely convolution based dose calculation approaches. It is demonstrated that the hybrid algorithm can efficiently calculate even complicated pencil beam and cross firing beam geometries. The required calculation times are substantially lower than for pure Monte Carlo calculations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.