ArticleJournal of affective disorders2018
Early life social stress and resting state functional connectivity in postpartum rat anterior cingulate circuits.
Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Neurobiological insights into perinatal depression: a multi-dimensional integration of brain structure, function, and metabolism.Frontiers in psychiatry · 2026Pooled it
- Maternal glucocorticoids have persistent effects on offspring social phenotype irrespective of opportunity for social buffering.The Journal of animal ecology · 2026Article
- Altered functional connectivity of emotional circuits and default mode network in postpartum women: a resting-state functional magnetic resonance imaging study.BMC psychology · 2026Article
- Hippocampal area CA2 activity supports social investigation following an acute social stress.Molecular psychiatry · 2025Article
- Depression in the next generation is related with maternal behaviors: A cross-comparison by alternating rat's mother care.PloS one · 2023Article
- Identifying reproducible resting state networks and functional connectivity alterations following chronic restraint stress in anaesthetized rats.Frontiers in neuroscience · 2023Article
- Chronic social stress during early development is involved in antisocial maltreatment behavior in mice.Encephalitis (Seoul, Korea) · 2022Article
- Ethologically relevant repeated acute social stress induces maternal neglect in the lactating female mouse.Developmental psychobiology · 2021Article
- Adaptations in reward-related behaviors and mesolimbic dopamine function during motherhood and the postpartum period.Frontiers in neuroendocrinology · 2020Review
- Sex Differences in Vulnerability and Resilience to Stress Across the Life Span.Biological psychiatry · 2019Review
- Early postpartum resting-state functional connectivity for mothers receiving buprenorphine treatment for opioid use disorder: A pilot study.Journal of neuroendocrinology · 2019Article
- The maternal reward system in postpartum depression.Archives of women's mental health · 2019Review
- A Resting-State Functional MR Imaging and Spectroscopy Study of the Dorsal Hippocampus in the Chronic Unpredictable Stress Rat Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Early-life social environment predicts social network position in wild zebra finches.Proceedings. Biological sciences · 2019Article
- Article
- Childhood Emotional Abuse Moderates Associations Among Corticomotor White Matter Structure and Stress Neuromodulators in Women With and Without Depression.Frontiers in neuroscience · 2018Article
- Multiscale Imaging Reveals Aberrant Functional Connectome Organization and Elevated Dorsal StriataleNeuroArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
introductionContinued development and refinement of resting state functional connectivity (RSFC) fMRI techniques in both animal and clinical studies has enhanced our comprehension of the adverse effects of stress on psychiatric health. The objective of the current study was to assess both maternal behavior and resting state functional connectivity (RSFC) changes in these animals when they were dams caring for their own young. It was hypothesized that ECSS exposed dams would express depressed maternal care and exhibit similar (same networks), yet different specific changes in RSFC (different individual nuclei) than reported when they were adult females.
methodsWe have developed an ethologically relevant transgenerational model of the role of chronic social stress (CSS) in the etiology of postpartum depression and anxiety. Initial fMRI investigation of the CSS model indicates that early life exposure to CSS (ECSS) induces long term changes in functional connectivity in adult nulliparous female F1 offspring.
resultsECSS in F1 dams resulted in depressed maternal care specifically during early lactation, consistent with previous CSS studies, and induced changes in functional connectivity in regions associated with sensory processing, maternal and emotional responsiveness, memory, and the reward pathway, with robust changes in anterior cingulate circuits. LIMITATIONS: The sample sizes for the fMRI groups were low, limiting statistical power.
conclusionThis behavioral and functional neuroanatomical foundation can now be used to enhance our understanding of the neural etiology of early life stress associated disorders and test preventative measures and treatments for stress related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.