Observational studyEnvironment international2018
How do glutathione antioxidant enzymes and total antioxidant status respond to air pollution exposure?
Observational study in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Acute exposure to traffic-related air pollution alters antioxidant status in healthy adults.Environmental research · 2020Trial
- Mega-Events, Air Pollution and Health Outcomes: A Systematic Review.Antioxidants (Basel, Switzerland) · 2026Review
- Association between Serum Uric Acid Levels and Salivary Microbiota in Patients with Obstructive Sleep Apnea.Journal of microbiology and biotechnology · 2025Article
- Status of Oxidative Stress during Low-Risk Labour: Preliminary Data.International journal of environmental research and public health · 2022Article
- Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation.International journal of molecular sciences · 2022Review
- Glutathione production by Saccharomyces cerevisiae: current state and perspectives.Applied microbiology and biotechnology · 2022Review
- Modified Qing'e Formula protects against UV-induced skin oxidative damageFrontiers in pharmacology · 2022Article
- Research advances in pathogenic mechanisms underlying air pollution-induced ocular surface diseases.Advances in ophthalmology practice and research · 2021Review
- Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway.Foods (Basel, Switzerland) · 2021Article
- Changes in arachidonic acid (AA)- and linoleic acid (LA)-derived hydroxy metabolites and their interplay with inflammatory biomarkers in response to drastic changes in air pollution exposure.Environmental research · 2021Article
- The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis.Antioxidants (Basel, Switzerland) · 2021Review
- Antioxidant, Anti-Aging and Organ Protective Effects of Total Saponins fromDrug design, development and therapy · 2021Article
- New Opportunities to Mitigate the Burden of Disease Caused by Traffic Related Air Pollution: Antioxidant-Rich Diets and Supplements.International journal of environmental research and public health · 2020Review
- Selenium Anticancer Properties and Impact on Cellular Redox Status.Antioxidants (Basel, Switzerland) · 2020Review
- Responses of serum chemokines to dramatic changes of air pollution levels, a panel study.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2019Article
- Metabolomics Profiling before, during, and after the Beijing Olympics: A Panel Study of Within-Individual Differences during Periods of High and Low Air Pollution.Environmental health perspectives · 2019Article
- Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases.Frontiers in pharmacology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
This study aims to investigate how antioxidant enzyme activity and overall antioxidant capacity respond to short-term changes in exposure to air pollution. 201 participants were recruited before- and followed up during- and after- the 2008 Beijing Olympics. Serum levels of antioxidant enzymes including glutathione S-transferases (GST), glutathione peroxidase (GPx), glutathione reductase (GR), and total antioxidant status (TAS) were measured. We used linear mixed-effects models to compare changes in antioxidant enzymes across the three periods after adjusting for potential confounding factors. Among all participants, glutathione peroxidase (GPx) levels decreased by 12.0% when air pollution dropped by 50-60% during the Olympics and increased by 6.5% when air pollution levels rose after the Olympics. The magnitude of increase among males, smokers, and older individuals was relatively smaller compared to females, nonsmokers, and younger individuals. Among all participants, total antioxidant status (TAS) significantly decreased by 6.23% during the games and continued to decrease by 4.41% after the games. However, among females, nonsmokers, and younger participants, there was an increase in TAS response to the elevated air pollution levels. Our study observed strong responses in GPx and TAS levels to the short-term decrease and increase of air pollution levels and responses varied among subgroups.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.