Evidence map›Paper›PMID 29323751›Full record

ArticleAnnals of neurology2018

[

Jennifer L Whitwell, Jonathan Graff-Radford, Nirubol Tosakulwong, Stephen D Weigand, Mary Machulda, Matthew L Senjem, Christopher G Schwarz, Anthony J Spychalla, David T Jones, Daniel A Drubach and 7 more

Abstract read
In one paragraph

Article in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Review
  7. Article
  8. Mapping individual molecular connectomes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Heterogeneous tau deposition patterns in the preclinical stage link to domain-specific cognitive deficits.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  15. Review
  16. Review
  17. Microscopy assessment of a fluorescence [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  18. Investigating the feasibility ofAlzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Observational
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, MN.
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, MN.
Nirubol TosakulwongDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN.
Stephen D WeigandDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN.
Mary MachuldaDepartment of Psychology and Psychiatry, Mayo Clinic, Rochester, MN.
Matthew L SenjemDepartment of Radiology, Mayo Clinic, Rochester, MN.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, MN.ORCID 0000-0002-1466-8357
Anthony J SpychallaDepartment of Radiology, Mayo Clinic, Rochester, MN.
David T JonesDepartment of Neurology, Mayo Clinic, Rochester, MN.
Daniel A DrubachDepartment of Neurology, Mayo Clinic, Rochester, MN.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN.
Nilüfer Ertekin-TanerDepartment of Neurology, Mayo Clinic, Jacksonville, FL.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USJacksonville College · US

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 1999 to 2018
$36.9M
Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, PETERS, METTE · 2013 to 2022
$24.6M
PREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1M
Integrative translational discovery of vascular risk factors in aging and dementiaRF1AG051504 · NIA · MAYO CLINIC JACKSONVILLE · PI BU, GUOJUN, ERTEKIN-TANER, NILUFER · 2015 to 2019
$9.8M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
Molecular and structural imaging in atypical Alzheimer's disease: a longitudinal studyR01AG050603 · NIA · MAYO CLINIC ROCHESTER · PI WHITWELL, JENNIFER LOUISE · 2016 to 2025
$5.9M
Gene discovery in PSP by transcriptome, neuropathology and sequence analysisR01NS080820 · NINDS · MAYO CLINIC JACKSONVILLE · PI ERTEKIN-TANER, NILUFER · 2013 to 2017
$1.8M
Assessment of hyperphosphorylated tau PET binding in primary progressive aphasiaR21NS094684 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2016 to 2017
$417k
NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG011378NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG050603NIA NIH HHS RF1 AG051504NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG046139NINDS NIH HHS R01 NS080820NINDS NIH HHS R21 NS094684
6 · The paper itself

Abstract

objectiveTo use a cluster analysis of [

methodsWe calculated [

resultsThe cluster analysis identified a cluster with low entorhinal and cortical uptake (E

interpretationThis study demonstrates considerable variability in [

Indexed as

AgedAlzheimer DiseaseCarbolinesCluster AnalysisEntorhinal CortexFemaleHumansImage Interpretation, Computer-AssistedMaleNeocortexNeuroimagingPhenotypePositron-Emission Tomography7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleCarbolines

Identifiers

PMID29323751
PMCPMC5821532
OpenAlexW2784231177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.