Evidence map›Paper›PMID 29323719›Full record

ReviewJournal of cellular physiology2018

The multifaceted link between inflammation and human diseases.

Peramaiyan Rajendran, Ya-Fang Chen, Yu-Feng Chen, Li-Chin Chung, Shanmugam Tamilselvi, Chia-Yao Shen, Cecilia Hsuan Day, Ray-Jade Chen, Vijaya P Viswanadha, Wei-Wen Kuo and 1 more

Abstract readReview
In one paragraph

Review in Journal of cellular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Calprotectin (S100A8/S100A9): a key protein between inflammation and cancer.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018
    Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Raspberry protective role in inflammatory diseases: An overview.Iranian journal of basic medical sciences · 2026
    Review
  10. Article
  11. BeyondInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Review
  14. Effect of Alligator Weed (Animals : an open access journal from MDPI · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Post-Acute Sequelae and Mitochondrial Aberration in SARS-CoV-2 Infection.International journal of molecular sciences · 2024
    Review
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peramaiyan RajendranGraduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Ya-Fang ChenDepartment of Obstetrics and Gynecology, Taichung Veteran's General Hospital, Taichung, Taiwan.
Yu-Feng ChenSection of Cardiology, Yuan Rung Hospital, Yuanlin, Taiwan.
Li-Chin ChungDepartment of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan County, Taiwan.
Shanmugam TamilselviGraduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Chia-Yao ShenDepartment of Nursing, MeiHo University, Pingtung, Taiwan.
Cecilia Hsuan DayDepartment of Nursing, MeiHo University, Pingtung, Taiwan.
Ray-Jade ChenDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Vijaya P ViswanadhaDepartment of Biotechnology, Bharathiar University, Coimbatore, India.
Wei-Wen KuoDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Chih-Yang HuangGraduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.ORCID http://orcid.org/0000-0003-2347-0411

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing reports on epidemiological, diagnostic, and clinical studies suggest that dysfunction of the inflammatory reaction results in chronic illnesses such as cancer, arthritis, arteriosclerosis, neurological disorders, liver diseases, and renal disorders. Chronic inflammation might progress if injurious agent persists; however, more typically than not, the response is chronic from the start. Distinct to most changes in acute inflammation, chronic inflammation is characterized by the infiltration of damaged tissue by mononuclear cells like macrophages, lymphocytes, and plasma cells, in addition to tissue destruction and attempts to repair. Phagocytes are the key players in the chronic inflammatory response. However, the important drawback is the activation of pathological phagocytes, which might result from continued tissue damage and lead to harmful diseases. The longer the inflammation persists, the greater the chance for the establishment of human diseases. The aim of this review was to focus on advances in the understanding of chronic inflammation and to summarize the impact and involvement of inflammatory agents in certain human diseases.

Indexed as

AnimalsChronic DiseaseHumansInflammationLeukocytes, MononuclearPhagocytesarthritisatherosclerosiscancerinflammationneurological disorders

Identifiers

PMID29323719
PMCPMC13482531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.