Trial reportPalliative medicine2018
Differential effects of early palliative care based on the age and sex of patients with advanced cancer from a randomized controlled trial.
Trial report in Palliative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Impact of Interdisciplinary Outpatient Specialty Palliative Care on Survival and Quality of Life in Adults With Advanced Cancer: A Meta-Analysis of Randomized Controlled Trials.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Pooled it
- Pilot Randomized Trial of a Transdisciplinary Geriatric and Palliative Care Intervention for Older Adults With Cancer.Journal of the National Comprehensive Cancer Network : JNCCN · 2020Trial
- Differential effects of an electronic symptom monitoring intervention based on the age of patients with advanced cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2020Trial
- Preference for Palliative Care in Cancer Patients: Are Men and Women Alike?Journal of pain and symptom management · 2018Trial
- Emergency department-initiated palliative care screening among older adults: a systematic review and meta-analysis protocol.BMJ open · 2025Article
- Review
- Public perceptions of advance care planning (ACP) from an international perspective: a scoping review.BMC palliative care · 2023Article
- A survey of hospice day services in the United Kingdom & Republic of Ireland : how did hospices offer social support to palliative care patients, pre-pandemic?BMC palliative care · 2022Review
- Communication of palliative care needs in discharge letters from hospice providers to primary care: a multisite sequential explanatory mixed methods study.BMC palliative care · 2022Article
- Patient reported outcomes in advanced penile cancer.Urologic oncology · 2022Article
- Use of Theoretical Frameworks in the Development and Testing of Palliative Care Interventions.Journal of pain and symptom management · 2022Review
- Convergence of Geriatrics and Palliative Care to Deliver Personalized Supportive Care for Older Adults With Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Understanding Treatment Tolerability in Older Adults With Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Management of Intractable Symptoms in Oncologic Care.Current oncology reports · 2021Review
- Older adults with cancer and their caregivers - current landscape and future directions for clinical care.Nature reviews. Clinical oncology · 2020Review
- Review
- Understanding and Addressing the Role of Coping in Palliative Care for Patients With Advanced Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Review
- Electronic symptom monitoring: not everyone fits the mold.Annals of oncology : official journal of the European Society for Medical Oncology · 2020Article
- Statewide Differences in Personality Associated with Geographic Disparities in Access to Palliative Care: Findings on Openness.Journal of palliative medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEarly palliative care interventions enhance patient outcomes, including quality of life, mood, and coping, but it remains unclear whether certain subgroups of patients are more likely to benefit from early palliative care. We explored whether age and sex moderate the improved outcomes seen with early palliative care.
methodsWe performed a secondary analysis of data from a randomized trial of 350 patients with advanced lung and non-colorectal gastrointestinal cancer. Patients received an early palliative care intervention integrated with oncology care or usual oncology care alone. We used linear regression to determine if age (older or younger than 65) and sex moderated the effects of the intervention on quality of life (Functional Assessment of Cancer Therapy-General (FACT-G)), depression symptoms (Patient Health Questionnaire 9 (PHQ-9)), and coping (Brief COPE) within lung and gastrointestinal subgroups.
resultsAt 24 weeks, younger patients with lung cancer receiving early palliative care reported increased use of active coping ( B = 1.74; p = 0.02) and decreased use of avoidant coping ( B = -0.97; p = 0.02), but the effects of early palliative care on these outcomes were not significant for older patients. Male patients with lung cancer assigned to early palliative care reported better quality of life (FACT-G: B = 9.31; p = 0.01) and lower depression scores (PHQ-9: B = -2.82; p = 0.02), but the effects of early palliative care on these outcomes were not significant for female patients. At 24 weeks, we found no age or sex moderation effects within the gastrointestinal cancer subgroup.
conclusionAge and sex moderate the effects of early palliative care for patients with advanced lung cancer. Early palliative care may need to be tailored to individuals' unique sociodemographic and clinical characteristics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.