ArticleNature structural & molecular biology2018
Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
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Article in Nature structural & molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81citing papers in PubMed
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Who cites it
81 citing papers in PubMed, 132 citations in OpenAlex.
- Perspectives on TRPV Channels in the Structural and Computational Revolution Era.Advances in experimental medicine and biology · 2026Review
- Suppression of TRPV5 Regulates Microglia-Mediated Neuroinflammation Following Status Epilepticus.Glia · 2025Article
- Evaluation of Small-Molecule Binding Site Prediction Methods on Membrane-Embedded Protein Interfaces.Journal of chemical information and modeling · 2025Article
- TRPV4 Channel in Neurological Disease: from Molecular Mechanisms to Therapeutic Potential.Molecular neurobiology · 2025Review
- A novel TRPV5/6-like channel from a scleractinian coral.PloS one · 2025Article
- Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists.Molecules (Basel, Switzerland) · 2024Article
- Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity.iScience · 2024Article
- Recent advances on the structure and the function relationships of the TRPV4 ion channel.Channels (Austin, Tex.) · 2024Review
- Calmodulin regulates TRPV5 intracellular trafficking and plasma membrane abundance.The Journal of physiology · 2024Article
- Nociceptive transient receptor potential ankyrin 1 (TRPA1) in sensory neurons are targets of the antifungal drug econazole.BMC pharmacology & toxicology · 2024Article
- Calcium signalling and transport in the kidney.Nature reviews. Nephrology · 2024Review
- Molecular details of ruthenium red pore block in TRPV channels.EMBO reports · 2024Article
- Structural mechanism of TRPV5 inhibition by econazole.Structure (London, England : 1993) · 2024Article
- Role of TRP Channels in Metabolism-Related Diseases.International journal of molecular sciences · 2024Review
- Non-canonical helical transitions and conformational switching are associated with characteristic flexibility and disorder indices in TRP and Kv channels.Channels (Austin, Tex.) · 2023Article
- Review
- Theoretical framework and experimental solution for the air-water interface adsorption problem in cryoEM.Biophysics reports · 2023Article
- Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis.Journal of translational medicine · 2023Review
- Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.Nature communications · 2023Article
- Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms.Frontiers in molecular neuroscience · 2023Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 1 country.
Taylor E T HughesDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
David T LodowskiDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Kevin W HuynhDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Aysenur YaziciDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
John Del RosarioDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Abhijeet KapoorDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sandip BasakDepartment of Physiology and Biophysics School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0003-4018-8020
Amrita SamantaDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Xu HanDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Sudha ChakrapaniDepartment of Physiology and Biophysics School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Z Hong ZhouCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Marta FilizolaDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-4382-8276
Tibor RohacsDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Seungil HanPfizer Research and Development, Groton, CT, USA.
Vera Y Moiseenkova-BellDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. vmb@pennmedicine.upenn.edu.ORCID 0000-0002-0589-4053
Case Western Reserve University · USRutgers, The State University of New Jersey · USCalifornia NanoSystems Institute · USIcahn School of Medicine at Mount Sinai · USPfizer (United States) · USTranslational Therapeutics (United States) · US
Funding
TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7MRegulation of sensory TRP channels by phospholipids and G-proteinsR01NS055159 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ROHACS, TIBOR · 2007 to 2022
$5.9MRegulation of the Intestinal Ca2+ Channels TRPV6R01GM093290 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI CARNEVALE, VINCENZO, ROHACS, TIBOR · 2011 to 2025
$4.9MInterdisciplinary Training in Virology and Gene TherapyT32AI060567 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WU, TING-TING · 2004 to 2018
$3.4MStructural Insights into TRPV Channel GatingR01GM103899 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOISEENKOVA-BELL, VERA · 2013 to 2021
$3.2MWest/Midwest Consortium for High-Resolution Cryo Electron MicroscopyU24GM116792 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AGBANDJE-MCKENNA, MAVIS, DOKLAND, TERJE · 2016 to 2020
$3.0MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MMOLECULAR MECHANISMS OF DESENSITIZATION AND DRUG MODULATION IN LIGAND-GATED ION CHANNELSR01GM108921 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI CHAKRAPANI, SUDHA · 2014 to 2018
$1.9MMolecular mechanisms of TRPV5 gatingR01GM129357 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOISEENKOVA-BELL, VERA · 2018 to 2021
$1.7MHIGH-END CRYOEM INSTRUMENT FOR UCLA ELECTRON IMAGING CTR FOR NANOMACHINES: AIDSS10RR023057 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2006 to 2006
$1.6MMolecular mechanism of TRPV1 activationR01GM131048 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI CARNEVALE, VINCENZO, ROHACS, TIBOR · 2019 to 2022
$1.4MDirect Detection Device for atomic resolution cryoEM of macromolecular complexesS10OD018111 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2014 to 2014
$598kNCRR NIH HHS S10 RR023057NEI NIH HHS P30 EY011373NIAID NIH HHS T32 AI060567NIGMS NIH HHS R01 GM093290NIGMS NIH HHS R01 GM103899NIGMS NIH HHS R01 GM108921NIGMS NIH HHS R01 GM129357NIGMS NIH HHS R01 GM131048NIGMS NIH HHS U24 GM116792NIH HHS S10 OD018111NIH HHS S10 OD018522NINDS NIH HHS R01 NS055159
Abstract
The transient receptor potential vanilloid 5 (TRPV5) channel is a member of the transient receptor potential (TRP) channel family, which is highly selective for Ca
Indexed as
Cryoelectron MicroscopyAnimalsCalciumCell MembraneEconazoleEpitopesHumansHydrophobic and Hydrophilic InteractionsIonsMolecular Dynamics SimulationMutationPhosphatidylinositolsProtein ConformationRabbitsRatsTRPV Cation ChannelsCalciumEconazoleEpitopesIonsPhosphatidylinositolsTRPV5 protein, humanTRPV Cation Channels
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