ArticleScientific reports2018
Lateral and Basal Amygdala Account for Opposite Behavioral Responses during the Long-Term Expression of Fearful Memories.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Article
- Human Amygdala Volumetric Patterns Convergently Evolved in Cooperatively Breeding and Domesticated Species.Human nature (Hawthorne, N.Y.) · 2023Article
- Sensing fear: fast and precise threat evaluation in human sensory cortex.Trends in cognitive sciences · 2023Review
- Socioeconomic disparities in sleep duration are associated with cortical thickness in children.Brain and behavior · 2023Article
- Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks.PLoS biology · 2022Article
- Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice.Frontiers in behavioral neuroscience · 2022Article
- Chronic Cerebral Hypoperfusion-induced Dysregulations of Hyperpolarization- activated Cyclic Nucleotide-gated, KCNQ and G Protein-coupled Inwardly Rectifying Potassium Channels Correlated with Susceptibility and Unsusceptibility to Anxiety Behaviors.Current neurovascular research · 2022Article
- Dissociated Role of Thalamic and Cortical Input to the Lateral Amygdala for Consolidation of Long-Term Fear Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Total Number and Ratio of GABAergic Neuron Types in the Mouse Lateral and Basal Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Interneuron Types and Their Circuits in the Basolateral Amygdala.Frontiers in neural circuits · 2021Review
- Dysregulation of inflammation, neurobiology, and cognitive function in PTSD: an integrative review.Cognitive, affective & behavioral neuroscience · 2020Review
- Amygdala Nuclei Volumes Are Selectively Associated With Social Network Size in Homeless and Precariously Housed Persons.Frontiers in behavioral neuroscience · 2020Article
- Reciprocal connectivity between secondary auditory cortical field and amygdala in mice.Scientific reports · 2019Article
- State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala.Nature neuroscience · 2019Article
- Fear not: recent advances in understanding the neural basis of fear memories and implications for treatment development.F1000Research · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Memories of fearful events can be maintained throughout the lifetime of animals. Here we showed that lesions of the lateral nucleus (LA) performed shortly after training impaired the retention of long-term memories, assessed by the concomitant measurement of two dissociable defensive responses, freezing and avoidance in rats. Strikingly, when LA lesions were performed four weeks after training, rats did not show freezing to a learned threat stimulus, but they were able to direct their responses away from it. Similar results were found when the central nucleus (CeA) was lesioned four weeks after training, whereas lesions of the basal nucleus (BA) suppressed avoidance without affecting freezing. LA and BA receive parallel inputs from the auditory cortex, and optogenetic inhibition of these terminals hampered both freezing and avoidance. We therefore propose that, at variance with the traditional serial flow of information model, long-term fearful memories recruit two parallel circuits in the amygdala, one relying on the LA-to-CeA pathway and the other relying solely on BA, which operate independently and mediate distinct defensive responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.