Evidence map›Paper›PMID 29323212›Full record

ArticleScientific reports2018

Multimodal tumor-homing chitosan oligosaccharide-coated biocompatible palladium nanoparticles for photo-based imaging and therapy.

Subramaniyan Bharathiraja, Nhat Quang Bui, Panchanathan Manivasagan, Madhappan Santha Moorthy, Sudip Mondal, Hansu Seo, Nguyen Thanh Phuoc, Thi Tuong Vy Phan, Hyehyun Kim, Kang Dae Lee and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  11. Metal-based nanoparticle in cancer treatment: lessons learned and challenges.Frontiers in bioengineering and biotechnology · 2024
    Review
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  13. A comprehensive review on potential applications of metallic nanoparticles as antifungal therapies to combat human fungal diseases.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
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  19. Antioxidant potential of nanomaterials.Turkish journal of biology = Turk biyoloji dergisi · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Subramaniyan BharathirajaMarine-Integrated Bionics Research Center, Pukyong National University, Busan, 48513, Republic of Korea.
Nhat Quang BuiDepartment of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan, 48513, Republic of Korea.ORCID http://orcid.org/0000-0001-7466-1416
Panchanathan ManivasaganMarine-Integrated Bionics Research Center, Pukyong National University, Busan, 48513, Republic of Korea.
Madhappan Santha MoorthyMarine-Integrated Bionics Research Center, Pukyong National University, Busan, 48513, Republic of Korea.
Sudip MondalMarine-Integrated Bionics Research Center, Pukyong National University, Busan, 48513, Republic of Korea.
Hansu SeoDepartment of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan, 48513, Republic of Korea.
Nguyen Thanh PhuocDepartment of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan, 48513, Republic of Korea.
Thi Tuong Vy PhanDepartment of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan, 48513, Republic of Korea.
Hyehyun KimDepartment of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan, 48513, Republic of Korea.
Kang Dae LeeDepartment of Otolaryngology - Head and Neck Surgery, Kosin University College of Medicine, Busan, Republic of Korea.
Junghwan OhMarine-Integrated Bionics Research Center, Pukyong National University, Busan, 48513, Republic of Korea. jungoh@pknu.ac.kr.ORCID http://orcid.org/0000-0002-5837-0958

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Palladium, a near-infrared plasmonic material has been recognized for its use in photothermal therapy as an alternative to gold nanomaterials. However, its potential application has not been explored well in biomedical applications. In the present study, palladium nanoparticles were synthesized and the surface of the particles was successfully modified with chitosan oligosaccharide (COS), which improved the biocompatibility of the particles. More importantly, the particles were functionalized with RGD peptide, which improves particle accumulation in MDA-MB-231 breast cancer cells and results in enhanced photothermal therapeutic effects under an 808-nm laser. The RGD peptide-linked, COS-coated palladium nanoparticles (Pd@COS-RGD) have good biocompatibility, water dispersity, and colloidal and physiological stability. They destroy the tumor effectively under 808-nm laser illumination at 2 W cm

Indexed as

AnimalsBiocompatible MaterialsCell Line, TumorCell SurvivalChitosanHumansLasersMetal NanoparticlesMiceMice, Inbred BALB CMice, NudeMicroscopy, FluorescenceMultimodal ImagingNeoplasmsOligopeptidesOligosaccharidesarginyl-glycyl-aspartic acidBiocompatible MaterialsChitosanOligopeptidesOligosaccharidesPalladium

Identifiers

PMID29323212
PMCPMC5764953

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.