ArticleScientific reports2018
Peptide-based coatings for flexible implantable neural interfaces.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Predicting Supramolecular Self-Assembly of Peptide Structures with AlphaFold3.bioRxiv : the preprint server for biology · 2026Article
- Molecular Mechanisms of Foreign Body Responses to Neural Electrodes and Surface Biofunctionalization Strategies for Interface Modulation.International journal of molecular sciences · 2026Review
- Design and Biofunctionalization of Cloud Sponge-Inspired Scaffolds for Enhanced Bone Cell Performance.ACS applied bio materials · 2024Article
- Characterization of a conductive hydrogel@Carbon fibers electrode as a novel intraneural interface.Bioelectronic medicine · 2024Article
- Antimicrobial peptides and their potential application in antiviral coating agents.Colloids and surfaces. B, Biointerfaces · 2022Review
- Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces.Micromachines · 2022Article
- Directional Growth of cm-Long PLGA Nanofibers by a Simple and Fast Wet-Processing Method.Materials (Basel, Switzerland) · 2022Article
- Aggregation Properties of Albumin in Interacting with Magnetic Fluids.International journal of molecular sciences · 2021Article
- Optimized design of a hyperflexible sieve electrode to enhance neurovascular regeneration for a peripheral neural interface.Biomaterials · 2021Article
- Progress and challenges of implantable neural interfaces based on nature-derived materials.Bioelectronic medicine · 2021Review
- Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants.Biomaterials · 2019Article
- Chronically Implanted Intracranial Electrodes: Tissue Reaction and Electrical Changes.Micromachines · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, the use of flexible biosensors for neuroprosthetic and translational applications has widely increased. Among them, the polyimide (PI)-based thin-film electrodes got a large popularity. However, the usability of these devices is still hampered by a non-optimal tissue-device interface that usually compromises the long-term quality of neural signals. Advanced strategies able to improve the surface properties of these devices have been developed in the recent past. Unfortunately, most of them are not easy to be developed and combined with micro-fabrication processes, and require long-term efforts to be testable with human subjects. Here we show the results of the design and in vitro testing of an easy-to-implement and potentially interesting coating approach for thin-film electrodes. In particular, two biocompatible coatings were obtained via covalent conjugation of a laminin-derived peptide, CAS-IKVAV-S (IKV), with polyimide sheets that we previously functionalized with vinyl- and amino- groups (PI_v and PI_a respectively). Both the engineered coatings (PI_v+IKV and PI_a+IKV) showed morphological and chemical properties able to support neuronal adhesion, neurite sprouting, and peripheral glial cell viability while reducing the fibroblasts contamination of the substrate. In particular, PI_v+IKV showed promising results that encourage further in vivo investigation and pave the way for a new generation of peptide-coated thin-film electrodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.