Evidence map›Paper›PMID 29323130›Full record

ArticleScientific reports2018

In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis.

Aina Farrán, Gladys Valverde-Franco, Laura Tío, Bertrand Lussier, Hassan Fahmi, Jean-Pierre Pelletier, Paul N Bishop, Jordi Monfort, Johanne Martel-Pelletier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Aina FarránOsteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
Gladys Valverde-FrancoOsteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
Laura TíoInflammation and Cartilage Cellular Research Group, IMIM (Hospital del Mar Medical Research Institute) Rheumatology Department, Parc de Salut Mar, Hospital del Mar, Barcelona, Spain.
Bertrand LussierOsteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
Hassan FahmiOsteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
Jean-Pierre PelletierOsteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
Paul N BishopManchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Jordi MonfortInflammation and Cartilage Cellular Research Group, IMIM (Hospital del Mar Medical Research Institute) Rheumatology Department, Parc de Salut Mar, Hospital del Mar, Barcelona, Spain.
Johanne Martel-PelletierOsteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada. jm@martelpelletier.ca.
Université de Montréal · CAHospital Del Mar · ESHospital del Mar Research Institute · ESManchester Royal Eye Hospital · GBMunicipal Institute for Medical Research · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SLRP opticin (OPTC) has been demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we investigated the in vivo effect of OPTC deficiency in OA cartilage. OA was induced in 10-week-old Optc

Indexed as

AnimalsCartilageDisease Models, AnimalExtracellular Matrix ProteinsFibromodulinGene DeletionGene Expression RegulationHumansLumicanMiceMice, TransgenicMicroscopy, Electron, TransmissionOsteoarthritisPrognosisProteoglycansSmall Leucine-Rich ProteoglycansEpyc protein, mouseExtracellular Matrix ProteinsFibromodulinFmod protein, mouseLumicanLum protein, mouseOptc protein, mouseProteoglycansSmall Leucine-Rich Proteoglycans

Identifiers

PMID29323130
PMCPMC5765138
OpenAlexW2781713547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.